To investigate the body burden of organochlorine pesticides and dioxins in Japanese women, 125 milk samples were collected from 41 mothers in 1994,42 in 1995, and 42 in 1996.
Of the 125 samples, 82 were from primipara mothers (first delivery) and 43 were from multipara mothers (second or later delivery).
By using capillary gas chromatography with electron capture detection, bêta-HCH and p, p'-DDE were detected as the major chlorine pesticides in human milk.
Average levels of bêta-HCH and p, p'-DDE were 475 and 368 ng/g lipid, respectively, in primipara breast milk, 314 and 259 ng/g lipid in multipara breast milk, and 420 and 330 ng/g lipid in total breast milk.
Dieldrin, heptachor epoxide, oxychlordane, trans-chlordane, and cis-chlordane were detected at lower average levels of 3,4,34,41, and 5 ng/g lipid, respectively.
By using high-resolution gas chromatography with mass spectrometric detection, dioxins were detected in all samples.
Average levels of total polychlorinated dibenzo-p-dioxin (PCDD), total polychlorinated dibenzofuran (PCDF), total PCDD+PCDF, total coplanar polychlorinatedbiphenyl (CoPCB), and total dioxin were 10.0,7.8,17.7,9.9, and 27.5 TEQ (toxic equivalent) pglg lipid, respectively, in primipara breast milk ; 7.0,5.8,12.8,7.3, and 20.1 TEQ pg/g lipid in multipara breast milk ; and 8.9,7.1,16.1,8.9, and 25.0 TEQ pglg lipid in total breast milk. (...)
Mots-clés Pascal : Japon, Asie, Analyse qualitative, Lait femme, Pesticide, Organochloré, Dibenzo-p-dioxine(polychloro), Dibenzo-p-dioxine(2,3,7,8-tétrachloro), Dioxine dérivé, Epidémiologie, Accumulation biologique, Chlore Composé organique, Xénobiotique, Analyse quantitative, Allaitement, Nourrisson, Homme, Age mère, Habitude alimentaire, Primiparité, Multiparité
Mots-clés Pascal anglais : Japan, Asia, Qualitative analysis, Human milk, Pesticides, Organochlorine compounds, Dioxin derivatives, Epidemiology, Biological accumulation, Chlorine Organic compounds, Xenobiotic, Quantitative analysis, Breast feeding, Infant, Human, Maternal age, Food habit, Primiparity, Multiparity
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0386155
Code Inist : 002B03G. Création : 22/03/2000.