Inhaled corticosteroids form the mainstay of the treatment and management of asthma and the results of a meta-analysis comparing two of the most frequently prescribed inhaled corticosteroids, fluticasone propionate and budesonide, administered in a clinically equivalent 1 : 2 dose ratio to 1980 patients with asthma, demonstrated that fluticasone propionate had an improved efficacy : safety ratio.
However, limited data are available on the relative economic benefits of fluticasone propionate and budesonide.
The database for clinically relevant parameters, for which the efficacy : safety meta-analysis had demonstrated statistical significance between the two corticosteroids, was used for this pharmacoeconomic analysis.
Treatment with fluticasone propionate was more cost-effective than budesonide with respect to improvement in morning peak expiratory flow rate, successfully treated weeks, symptom-free days, symptom-free 24 h and episode-free days.
The costs of treatment for fluticasone propionate and budesonide were £7.78 per week and £12.33 per week, respectively.
The main contributing factor to the higher costs of budesonide was the higher cost of health care contacts, which were £4.53 per week for budesonide and £0.57 per week for fluticasone propionate.
The pharmacoeconomic difference increased in favour of fluticasone propionate as the criteria for success were made more stringent. (...)
Mots-clés Pascal : Asthme, Chimiothérapie, Traitement, Budésonide, Efficacité traitement, Etude comparative, Fluticasone, Coût, Economie santé, Enfant, Homme, Adulte, Corticostéroïde, Appareil respiratoire pathologie, Bronchopneumopathie obstructive, Antiasthmatique, Antiinflammatoire
Mots-clés Pascal anglais : Asthma, Chemotherapy, Treatment, Budesonide, Treatment efficiency, Comparative study, Fluticasone, Costs, Health economy, Child, Human, Adult, Corticosteroid, Respiratory disease, Obstructive pulmonary disease, Antiasthma agent, Antiinflammatory agent
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0380056
Code Inist : 002B02D. Création : 22/03/2000.