Effects of the National Cholesterol Education Program's Step I and Step II dietary intervention programs on cardiovascular disease risk factors : a meta-analysis.
Plasma lipid and lipoprotein responses have been variable in dietary intervention studies.
The objective of this study was to evaluate the effects of the National Cholesterol Education Program's Step I and Step II dietary interventions on major cardiovascular disease risk factors using meta-analysis.
MEDLINE was used to select 37 dietary intervention studies in free-living subjects published from 1981 to 1997.
Step I and Step II dietary interventions significantly decreased plasma lipids and lipoproteins.
Plasma total cholesterol (TC), LDL cholesterol, triacylglycerol, and TC : HDL cholesterol decreased by 0.63 mmol/L (10%), 0.49 mmol/L (12%), 0.17 mmol/L (8%), and 0.50 (10%), respectively, in Step I intervention studies, and by 0.81 mmol/L (13%), 0.65 mmol/L (16%), 0.19 mmol/L (8%), and 0.34 (7%), respectively, in Step II intervention studies (P<0.01 for all).
HDL cholesterol decreased by 7% (P=0.05) in response to Step II but not to Step I dietary interventions.
Positive correlations between changes in dietary total and saturated fatty acids and changes in TC and LDL and HDL cholesterol were observed (r=0.59,0.61, and 0.46, respectively : P<0.001).
Multiple regression analyses showed that for every 1% decrease in energy consumed as dietary saturated fatty acid, TC decreased by 0.056 mmol/L and LDL cholesterol by 0.05 mmol/L. Moreover, for every 1-kg decrease in body weight, triacylglycerol decreased by 0. (...)
Mots-clés Pascal : Education nutritionnelle, Programme, Facteur risque, Cardiopathie coronaire, Cholestérol, Cholestérol LDL, Etats Unis, Amérique du Nord, Amérique, Poids corporel, Biométrie corporelle, Métaanalyse, Appareil circulatoire pathologie, Lipide, Homme
Mots-clés Pascal anglais : Nutrition education, Program, Risk factor, Coronary heart disease, Cholesterol, Cholesterol LDL, United States, North America, America, Body weight, Corporal biometry, Metaanalysis, Cardiovascular disease, Lipids, Human
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0380011
Code Inist : 002B12A03. Création : 22/03/2000.