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  1. Fulltext. Effects of the National Cholesterol Education Program's Step I and Step II dietary intervention programs on cardiovascular disease risk factors : a meta-analysis.

    Article - En anglais



    Plasma lipid and lipoprotein responses have been variable in dietary intervention studies.


    The objective of this study was to evaluate the effects of the National Cholesterol Education Program's Step I and Step II dietary interventions on major cardiovascular disease risk factors using meta-analysis.


    MEDLINE was used to select 37 dietary intervention studies in free-living subjects published from 1981 to 1997.


    Step I and Step II dietary interventions significantly decreased plasma lipids and lipoproteins.

    Plasma total cholesterol (TC), LDL cholesterol, triacylglycerol, and TC : HDL cholesterol decreased by 0.63 mmol/L (10%), 0.49 mmol/L (12%), 0.17 mmol/L (8%), and 0.50 (10%), respectively, in Step I intervention studies, and by 0.81 mmol/L (13%), 0.65 mmol/L (16%), 0.19 mmol/L (8%), and 0.34 (7%), respectively, in Step II intervention studies (P<0.01 for all).

    HDL cholesterol decreased by 7% (P=0.05) in response to Step II but not to Step I dietary interventions.

    Positive correlations between changes in dietary total and saturated fatty acids and changes in TC and LDL and HDL cholesterol were observed (r=0.59,0.61, and 0.46, respectively : P<0.001).

    Multiple regression analyses showed that for every 1% decrease in energy consumed as dietary saturated fatty acid, TC decreased by 0.056 mmol/L and LDL cholesterol by 0.05 mmol/L. Moreover, for every 1-kg decrease in body weight, triacylglycerol decreased by 0. (...)

    Mots-clés Pascal : Education nutritionnelle, Programme, Facteur risque, Cardiopathie coronaire, Cholestérol, Cholestérol LDL, Etats Unis, Amérique du Nord, Amérique, Poids corporel, Biométrie corporelle, Métaanalyse, Appareil circulatoire pathologie, Lipide, Homme

    Mots-clés Pascal anglais : Nutrition education, Program, Risk factor, Coronary heart disease, Cholesterol, Cholesterol LDL, United States, North America, America, Body weight, Corporal biometry, Metaanalysis, Cardiovascular disease, Lipids, Human

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0380011

    Code Inist : 002B12A03. Création : 22/03/2000.