Traditional Risk factors and subclinical disease measures as predictors of first myocardial infarction in older adults : The Cardiovascular Health study.
Risk factors for myocardial infarction (MI) have not been well characterized in older adults, and in estimating risk, we sought to assess the individual and joint contributions made by both traditional risk factors and measures of subclinical disease.
In the Cardiovascular Health Study, we recruited 5888 adults aged 65 years and older from 4 US centers.
At baseline in 1989-1990, participants underwent an extensive examination that included traditional risk factors such as blood pressure and fasting glucose level and measures of subclinical disease as assessed by electrocardiography, carotid ultrasonography, echocardiography, pulmonary function, and ankle-arm index.
Participants were followed up with semiannual contacts, and all cardiovascular events were classified by the Morbidity and Mortality Committee.
The main analytic technique was the Cox proportional hazards model.
At baseline, 1967 men and 2979 women had no history of an MI.
After follow-up for an average of 4.8 years, there were 302 coronary events, which included 263 patients with MI and 39 with definite fatal coronary disease.
The incidence was higher in men (20.7 per 1000 person-years) than women (7.9 per 1000 person-years).
In all subjects, the incidence was strongly associated with age, increasing from 7.8 per 1000 person-years in subjects aged 65 to 69 years to 25.6 per 1000 person-years in subjects aged 85 years and older. (...)
Mots-clés Pascal : Infarctus, Myocarde, Personne âgée, Homme, Incidence, Etude comparative, Sexe, Age, Facteur risque, Epidémiologie, Etats Unis, Amérique du Nord, Amérique, Appareil circulatoire pathologie, Cardiopathie coronaire, Myocarde pathologie
Mots-clés Pascal anglais : Infarct, Myocardium, Elderly, Human, Incidence, Comparative study, Sex, Age, Risk factor, Epidemiology, United States, North America, America, Cardiovascular disease, Coronary heart disease, Myocardial disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0379443
Code Inist : 002B30A01A2. Création : 22/03/2000.