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  1. Large incidence variation of Type I diabetes in central-southern italy 1990-1995 : lower risk in rural areas.

    Article - En anglais

    Aims/hypothesis

    To evaluate the relation between the incidence of childhood Type I (insulin-dependent) diabetes mellitus and the degree of urbanization in the central-southern part of Italy.

    Methods

    The incidence was determined in two areas : area A encompasses 3 regions of central-eastern Italy (Marche, Abruzzo, Umbria), whereas area B encompasses one southern region (Campania).

    During 1990-1995,706 children aged 14 or under with insulin-dependent diabetes mellitus of recent onset were registered.

    The completeness of the case ascertainment in the registries analysed separately for each region was high, ranging from 96.3% to 99%. Results.

    The age-standardized incidence was higher in area A (9.6 per 100 000 person per year ; 95% confidence interval : 8.5-10.8) than in area B (5.4 per 100000 person per year ; 95% confidence interval : 4.9-6.0).

    In both areas the standardized incidence ratios increased with the degree of urbanization (chi-squared for trend : area A=140, p<0.0001 ; area B=79, p<0.0001).

    The highest standardized incidence ratios were in the most urban communities.

    Conclusion/interpretation

    This study showed a statistically significant difference in incidence of childhood insulin-dependent diabetes mellitus among different areas of the continental peninsula of Italy.

    People living in the rural communities appear to have a lower risk.

    Mots-clés Pascal : Epidémiologie, Facteur risque, Urbanisation, Incidence, Diabète insulinodépendant, Endocrinopathie, Immunopathologie, Maladie autoimmune, Enfant, Homme, Milieu rural, Italie, Europe, Milieu urbain

    Mots-clés Pascal anglais : Epidemiology, Risk factor, Urbanization, Incidence, Insulin dependent diabetes, Endocrinopathy, Immunopathology, Autoimmune disease, Child, Human, Rural environment, Italy, Europe, Urban environment

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0379398

    Code Inist : 002B21E01A. Création : 22/03/2000.