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  1. Preimmunization epidemiology of hepatitis B virus infection in South African children.

    Article - En anglais

    The prevalence of hepatitis B surface antigen (HBsAg) was determined in a community-based, cross-sectional, age-stratified sample of children from 0 to 6 years of age (n=2,299) from the Eastern Cape Province of South Africa.

    The purpose of the study was to investigate the epidemiology and the age of acquisition of hepatitis B virus (HBV) infection in children, thus providing a preimmunization baseline measure of this infection in the population targeted for HBV immunization in South Africa.

    Overall, 10.4% (95% Cl, 9.2-11.7) of the children tested were HBsAg-positive.

    There was a high rate of positivity in the 0-6-and 7-12-month age groups at 8.1% (95% Cl, 5.5-11.7) and 8.9% (95% Cl, 6.1-12.7), respectively, suggesting a higher rate of early acquisition of this infection than previously reported in South Africa.

    The proportion of HBsAg-positive children increased significantly with increasing age (X2trend=5.9, df=1, P=0.02), reaching 15.7% in the 61-72-month age group.

    This is the highest rate of HBV infection reported in community-based children from South Africa, indicating a significant burden of this infection.

    The difference in HBsAg prevalence between urban and rural children was not statistically significant (X2=0.32, df=1, P=0.57).

    There was also no difference in positivity between males (10.5% ; 95% Cl, 8.7-12.5) and females (9.8% ; 95% Cl, 8.1-11.7), (X2=0.006, df=1, P=0.94). (...)

    Mots-clés Pascal : Virus hépatite B, Orthohepadnavirus, Hepadnaviridae, Virus, Nouveau né, Homme, Nourrisson, Enfant, Epidémiologie, Programme sanitaire, Prévalence, Sérologie, Antigène HBs, Analyse quantitative, Vaccination, Hépatite virale B, Virose, Infection, Appareil digestif pathologie, Foie pathologie, République Sud Africaine, Afrique

    Mots-clés Pascal anglais : Hepatitis B virus, Orthohepadnavirus, Hepadnaviridae, Virus, Newborn, Human, Infant, Child, Epidemiology, Sanitary program, Prevalence, Serology, Hepatitis B surface antigen, Quantitative analysis, Vaccination, Viral hepatitis B, Viral disease, Infection, Digestive diseases, Hepatic disease, South Africa(Republic), Africa

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0377064

    Code Inist : 002B05C02G. Création : 22/03/2000.