Exposure to environmentally and occupationally encountered toxicants can be associated with the development of certain autoimmune diseases and with the induction of antinuclear antibodies (ANA Some chemicals used in the agricultural industry are known to affect immune function but their roles in the induction of autoimmunity in general, and ANA in particular, have not been reported previously.
This study was undertaken to establish the prevalence of ANA in a rural population and to determine environmental and occupational exposures with which they are associated.
This cross-sectional study represented one component of an interdisciplinary project (Prairie Ecosystem Study [PECOS], Eco-Research Program, Tri-Council Secretariat of Canada) designed to explore, in a rural population, the roles of environmental exposures as determinants of human health status.
Information regarding lifetime, current, and main occupational exposures in the rural-dwelling study population was derived from a self-administered questionnaire.
Sera from consenting subjects, collected during the months of February and March 1996, were assayed for ANA by indirect immunofluorescence on HEp-2 cells.
The study population comprised 322 adult subjects (mean age 49.3 ± 14.7 yr ; range 16-87 yr). (...)
Mots-clés Pascal : Epidémiologie, Homme, Zone rurale, Anticorps, Autoanticorps, Maladie système, Système immunitaire, Maladie autoimmune, Immunopathologie, Exposition professionnelle, Pesticide, Production agricole, Population rurale, Age
Mots-clés Pascal anglais : Epidemiology, Human, Rural area, Antibody, Autoantibody, Systemic disease, Immune system, Autoimmune disease, Immunopathology, Occupational exposure, Pesticides, Agricultural production, Rural populations, Age
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0376650
Code Inist : 002B30A01A2. Création : 22/03/2000.