Transmission of antiretroviral drug-resistant HIV-1 variants.
Resistance of HIV-1 to antiretroviral drugs is the main cause of antiretroviral-treatment failure.
We assessed the transmission of drug resistant variants among individuals with primary HIV-1 infection.) Methods : Population based sequencing of the viral reversetranscriptase and protease genes derived from plasma viral RNA was done in 82 consecutive individuals with documented primary HIV-1 infection from January, 1996, to July, 1998.
Phenotypic resistance to protease inhibitors was assessed by recombinant virus assay in individuals with two or more mutations associated with resistance to protease inhibitors.
Zidovudine-resistance mutations were detected in seven (9%) of 82 individuals.
Mutations associated with resistance to other reverse-transcriptase inhibitors (RTIs) were detected in two individuals.
Primary-resistance mutations associated with protease inhibitors (V82A, L90M) were detected in three (4%) of 70 individuals ; two of these had also RTI-resistance mutations.
Decreased sensitivity to three or four protease inhibitors was seen in three individuals, one of whom was infected with HIV-1 variants that harboured 12 mutations associated with resistance to multiple RTI and protease inhibitors.
Interpretation To introduce the best antiretroviral treatment, resistance testing should be done in recently HIV-infected individuals.
Mots-clés Pascal : Infection, Prévention, Chimiothérapie, Traitement, Médicament, Sensibilité résistance, Virus immunodéficience humaine, Homme, Toxicomanie
Mots-clés Pascal anglais : Infection, Prevention, Chemotherapy, Treatment, Drug, Sensitivity resistance, Human immunodeficiency virus, Human, Drug addiction
Notice produite par :
ENSP - Ecole nationale de la santé publique (devenue EHESP)
Cote : 99/08 V
Code Inist : 002B30A11. Création : 22/03/2000.