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  1. The effects of supplementation with alpha-tocopherol and bêta-carotene on the incidence and mortality of carcinoma of the pancreas in a randomized, controlled trial.

    Article - En anglais


    Dietary components may be both causal and protective in cases of pancreatic carcinoma, but the preventive potential of single constituents has not been evaluated.

    The authors report the effects of alpha-tocopherol and bêta-carotene supplementations on the rates of incidence of and mortality from pancreatic carcinoma in a randomized, controlled trial.


    The 29,133 participants in the Alpha-Tocopherol Beta-Carotene Cancer Prevention (ATBC) Study were male smokers who were ages 50-69 years at the time they were randomized into 1 of the following 4 intervention groups : dl-alpha-tocopherol (AT ; 50 mg/day), bêta-carotene (BC ; 20 mg/day), both AT and BC, and placebo.

    The daily supplementation lasted for 5-8 years.

    Incident cancers were identified through the national Finnish Cancer Registry and death certificates of the Statistics Finland.

    Results were analyzed by supplementation with Cox regression models.


    Effects of both supplementations were statistically nonsignificant.

    The rate of incidence of pancreatic carcinoma was 25% lower for the men who received bêta-carotene supplements (n=38) compared with the rate for those who did not receive bêta-carotene (n=51) (95% Cl, - 51% to 14%). Supplementation with alpha-tocopherol (n=51) increased the rate of incidence by 34% (95% Cl, - 12% to 105%) compared with the rate for those who did not receive alpha-tocopherol. (...)

    Mots-clés Pascal : Carcinome, Pancréas, Supplémentation, alpha-Tocophérol, Vitamine E, Bétacarotène, Incidence, Mortalité, Epidémiologie, Prévention, Finlande, Europe, Homme, Tumeur maligne, Pancréas pathologie, Appareil digestif pathologie

    Mots-clés Pascal anglais : Carcinoma, Pancreas, Supplementation, alpha-Tocopherol, E-Vitamins, Betacarotene, Incidence, Mortality, Epidemiology, Prevention, Finland, Europe, Human, Malignant tumor, Pancreatic disease, Digestive diseases

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0371354

    Code Inist : 002B13C01. Création : 14/12/1999.