Objectives-To study longitudinal biological monitoring data on urinary and blood cadmium collected in a small cohort of nine workers who had been brazing for several years with solders containing cadmium.
Methods-Cadmium was measured by neutron activation analysis in livers and kidneys, and estimates of renal function were carried out in 1983 and 1995.
During the intervening period exposure to cadmium was dramatically reduced by local exhaust ventilation control and substitution of the solder containing cadmium.
From urinary protein measurements there was evidence within the group of increasing renal tubular damage over the 12 year period, even though exposure to cadmium was dramatically reduced over this period and almost eliminated by 1995.
There was no evidence from serum creatinine of decreasing glomerular filtration rate, and the renal tubular handling of calcium, phosphate, or urate had not worsened significantly.
Blood and urinary cadmium concentrations reduced significantly over the 12 year period but were still substantial in 1995.
Blood cadmium concentrations tended to reflect cadmium body burden in 1995 when exposure had been low for several years, and decreased most significantly during 1983-90.
By contrast urinary cadmium concentrations only decreased significantly from about 1990 onwards.
Urinary cadmium was not significantly correlated with liver or kidney cadmium concentration in either 1983 or 1995. (...)
Mots-clés Pascal : Brasage tendre, Argent, Cadmium, Métal lourd, Toxicité, Exposition professionnelle, Médecine travail, Homme, Surveillance biologique, Urine, Sang, Rein, Appareil urinaire pathologie
Mots-clés Pascal anglais : Soldering, Silver, Cadmium, Heavy metal, Toxicity, Occupational exposure, Occupational medicine, Human, Biological monitoring, Urine, Blood, Kidney, Urinary system disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0362617
Code Inist : 002B03L05. Création : 14/12/1999.