Antioxidants increase the resistance of low-density lipoprotein to oxidation and may thereby reduce risk for atherosclerosis.
To determine whether intake of vitamin E, vitamin C, or carotenoids predict risk for total or ischemic stroke.
Prospective observational study.
The Health Professionals Follow-up Study.
43 738 men 40 to 75 years of age who did not have cardiovascular disease or diabetes.
Repeated and validated dietary assessments were done by using a self-administered 131-item food-frequency questionnaire, which included questions on dose and duration of vitamin supplement use.
The follow-up period was 8 years.
A total of 328 strokes occurred : 210 ischemic, 70 hemorrhagic, and 48 unclassified.
After adjustment for age, smoking, hypertension, hypercholesterolemia, body mass index, physical activity, parental history of myocardial infarction, alcohol consumption, and total energy intake, the relative risk for ischemic stroke in the top quintile of vitamin E intake (median, 411 lU/d) compared with the bottom quintile (5.4 lU/d) was 1.18 (95% Cl, 0.77 to 1.82).
The relative risk for ischemic stroke in the top quintile of vitamin C intake (1167 mg/d) compared with the bottom quintile (95 mg/d) was 1.03 (Cl, 0.66 to 1.59).
Associations of vitamin intake with hemorrhagic stroke were also nonsignificant, but the Cls were wide. (...)
Mots-clés Pascal : Accident cérébrovasculaire, Athérosclérose, Supplémentation, Vitamine E, Acide ascorbique, Caroténoïde, Prévention, Facteur risque, Questionnaire, Etude cohorte, Analyse multivariable, Evaluation, Etats Unis, Amérique du Nord, Amérique, Homme, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie, Cérébrovasculaire pathologie, Appareil circulatoire pathologie, Vaisseau sanguin pathologie, Vitamine
Mots-clés Pascal anglais : Stroke, Atherosclerosis, Supplementation, E-Vitamins, Ascorbic acid, Carotenoid, Prevention, Risk factor, Questionnaire, Cohort study, Multivariate analysis, Evaluation, United States, North America, America, Human, Nervous system diseases, Central nervous system disease, Cerebral disorder, Cerebrovascular disease, Cardiovascular disease, Vascular disease, Vitamin
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0362136
Code Inist : 002B02N. Création : 14/12/1999.