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  1. Translating Clinical trial results into practice : The effect of an AIDS Clinical trial on prescribed antiretroviral therapy for HIV-infected pregnant women.

    Article - En anglais

    Background 

    The success of Pediatric AIDS Clinical Trials Group (PACTG) Protocol 076 in preventing vertical HIV transmission prompted intensive efforts to inform lay-persons and professionals about the trial's results.

    Objective 

    To explore community responsiveness to these efforts by assessing temporal, maternal, and health care factors associated with prescribed antiretroviral therapy before and after PACTG Protocol 076.

    Design 

    Retrospective cohort study.

    Setting 

    New York State Medicaid program.

    Patients 

    2607 HlV-infected women who delivered a living child between January 1993 and September 1996.

    Measurements 

    Adjusted odds of being prescribed antiretroviral treatment in the second or third trimester for women who delivered in period 1 (during the trial [January 1993 to February 1994]), period 2 (after the trial's end and announcement of the results to publication of the results [March 1994 to November 1994]), and period 3 (after publication of the trial results [December 1994 to September 1996]). Results : The adjusted odds of being prescribed antiretroviral therapy increased 21% per month in period 2 and decreased to 3% per month in period 3. In all time periods, the adjusted odds of being prescribed antiretroviral therapy were at least 60% greater (P<0.05) for women who were treated at an institution that performed HIV clinical trials, received HlV-focused ambulatory care, or had adequate prenatal care visits. (...)

    Mots-clés Pascal : SIDA, Virose, Infection, Virus immunodéficience humaine, Lentivirus, Retroviridae, Virus, Facteur risque, Gestation, Protocole thérapeutique, Chimiothérapie, Antiviral, Etude cohorte, Rétrospective, Communication information, Prévention, Prescription médicale, Femelle, Homme, Immunopathologie, Immunodéficit, Appareil génital femelle pathologie, Antirétroviral

    Mots-clés Pascal anglais : AIDS, Viral disease, Infection, Human immunodeficiency virus, Lentivirus, Retroviridae, Virus, Risk factor, Pregnancy, Therapeutic protocol, Chemotherapy, Antiviral, Cohort study, Retrospective, Information communication, Prevention, Medical prescription, Female, Human, Immunopathology, Immune deficiency, Female genital diseases

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0361730

    Code Inist : 002B05C02D. Création : 14/12/1999.