To describe the changes over time in incidence of hospital admissions among patients with HIV, reasons for hospital admission, duration of stay, relationship with CD4 T-cell count and with antiretroviral treatment.
The incidence of hospital admissions during each calendar year from 1988 to 1997 inclusive was calculated using a person-years analysis.
In addition the proportion of patient follow-up spent in hospital and the impact of changing treatment regimens among all patients with HIV aged >= 14 years and with at least one CD4 T-cell count seen at the Royal Free Hospital, London was also described.
A total of 1806 patients were investigated with median follow-up of 21.1 months.
Among all patients, the proportion of follow-up time spent as an in-patient decreased from 3.9% in 1988 to 1.3% in 1997 (P=0.0015 ; test for trend).
Hospital admissions for any cause peaked during 1989 at 72.0 per 100 patient years of follow-up (PYFU) and was 28.5 per 100 PYFU during 1997 (P<0.0001 ; test for trend).
There was a statistically significant decline in the proportion of follow-up time spent as an in-patient among patients with CD4 T-cell counts of <= 50 x 106/l from>30% before 1990 to<5% during 1997 (P=0.026 ; test for trend).
Hospital admissions varied greatly according to treatment regimen ; in 1996 and 1997 just 0.1% of follow-up time of patients on triple antiretroviral treatment regimens was spent as a hospital admission. (...)
Mots-clés Pascal : SIDA, Virose, Infection, Admission hôpital, Incidence, Durée, Hospitalisation, Etiologie, Hôpital, Homme, Epidémiologie, Facteur risque, Immunité cellulaire, Lymphocyte T, Traitement, Angleterre, Grande Bretagne, Royaume Uni, Europe, Immunopathologie, Immunodéficit, Protocole HAART
Mots-clés Pascal anglais : AIDS, Viral disease, Infection, Hospital admission, Incidence, Duration, Hospitalization, Etiology, Hospital, Human, Epidemiology, Risk factor, Cellular immunity, T-Lymphocyte, Treatment, England, Great Britain, United Kingdom, Europe, Immunopathology, Immune deficiency
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0361337
Code Inist : 002B05C02D. Création : 14/12/1999.