Vinyl chloride (VC) workers are known to be at risk for development of angiosarcoma of the liver (ASL), a rare tumor.
Previously, a study of p53 gene mutations in tumors of VC-exposed workers found that 50% of liver angiosarcomas contained such mutations.
Mutant p53 oncoprotein and anti-p53 antibodies can also be found in the sera of ASL patients and VC-exposed workers without cancer.
Workers in Taiwan have also been exposed to VC, and some have contracted liver tumors.
In this study, we used enzyme-linked immunosorbent assays to detect. mutant p53 protein and anti-p53 antibodies in the plasma of VC-exposed workers in Taiwan.
Thirty-three of 251 (13.2%) VC-workers tested positive for the p53 overexpression (10% with positive mutant p53 protein and 3.6% with positive anti-p53) in their plasma, but only 2 of36 controls (5.6%) tested positive (2.8% with positive mutant p53 protein and 2.8% with positive anti-p53).
There was a significant association between cumulative VC exposure concentration and positive p53 expression (P=0.032) among VC workers after we adjusted for age, hepatitis, drinking, and smoking status.
In summary, P53 overexpression (mutant p53 protein or anti-p53 antibody) can be found in the plasma of VC workers in Taiwan, and a significant dose-response relationship exists between plasma p53 overexpression and VC cumulative exposure concentration.
Mots-clés Pascal : Ethylène(chloro), Exposition professionnelle, Médecine travail, Homme, Toxicité, Angiosarcome, Foie, Mutation, Gène TP53, Expression génique, Surexpression génique, Carcinogène, Epidémiologie moléculaire, Marqueur tumoral, Appareil digestif pathologie, Marqueur biologique, Sarcome, Taiwan, Asie, Appareil circulatoire pathologie, Vaisseau sanguin pathologie, Tumeur maligne
Mots-clés Pascal anglais : Ethylene(chloro), Occupational exposure, Occupational medicine, Human, Toxicity, Angiosarcoma, Liver, Mutation, TP53 Gene, Gene expression, Gene overexpression, Carcinogen, Molecular epidemiology, Tumoral marker, Digestive diseases, Biological marker, Sarcoma, Taiwan, Asia, Cardiovascular disease, Vascular disease, Malignant tumor
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0357630
Code Inist : 002B03L06. Création : 14/12/1999.