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  1. Influence of renal biomarker variability on the design and interpretation of occupational or environmental studies.

    Article - En anglais


    To quantify and identify sources of within-and between-subject variability of microalbumin, N-acetyl-bêta-D-glucosaminidase (NAG) and alanine aminopeptidase (AAP), three biomarkers used for early detection of renal injury, and to assess the consequences of this variability for the design and power of epidemiological studies.


    Urinary excretion of microalbumin, NAG, AAP and creatinine as well as blood pressure (BP) were measured three times over a 2-year period among 142 healthy male workers.

    To minimise physiopathological and analytical sources of variation, standardised methods were used for urine collection and assays, and severe exclusion criteria were applied.

    At the first and third examinations, subjects completed the same questionnaire, providing information about their personal characteristics, tobacco and alcohol consumption, and health.

    A linear mixed model was used to estimate the within-and between-subject variance components and to analyse the relation between subjects'characteristics and the biomarkers.


    No change in the mean value of any of the biomarkers was observed over the 2-year period.

    Intra-class correlation coefficients between repeated measurements were 0.53,0.57 and 0.56 for microalbumin, NAG and AAP, respectively ; the between-subject variance was slightly higher than the within-subject variance.

    Subjects'age, BP, body mass index and smoking and drinking habits explained 7.2%, 12.5% and 4. (...)

    Mots-clés Pascal : Etude longitudinale, Epidémiologie, Médecine travail, Exposition professionnelle, Homme, Imprimerie, France, Europe, Toxicité, Chronique, Naphtalène, Hydrocarbure, Composé aromatique, Rein, Appareil urinaire pathologie, Analyse statistique, Marqueur biologique, Microalbuminurie, bêta-N-Acetylhexosaminidase, O-Glycosidases, Glycosidases, Hydrolases, Enzyme, Membrane alanyl aminopeptidase, Aminopeptidases, Peptidases, 1991-1993

    Mots-clés Pascal anglais : Follow up study, Epidemiology, Occupational medicine, Occupational exposure, Human, Printing plant, France, Europe, Toxicity, Chronic, Naphthalene, Hydrocarbon, Aromatic compound, Kidney, Urinary system disease, Statistical analysis, Biological marker, Microalbuminuria, bêta-N-Acetylhexosaminidase, O-Glycosidases, Glycosidases, Hydrolases, Enzyme, Membrane alanyl aminopeptidase, Aminopeptidases, Peptidases

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0357193

    Code Inist : 002B30B01A. Création : 14/12/1999.