An association between polyneuropathy and occupational exposure to trichloroethylene, trichloroethane, perchloroethylene, or similar solvents alone or in combination is controversial.
We sought to determine whether workers previously diagnosed with solvent-induced toxic encephalopathy had objective evidence of polyneuropathy.
Thirty railroad workers previously diagnosed with toxic encephalopathy were examined in the context of litigation against their employers.
All described long-term occupational solvent exposure averaging 20 years in duration (range, 10 to 29 years) and producing acute intoxication on a regular basis.
The diagnosis of subclinical or clinical polyneuropathy was established using a combination of symptoms, signs, and nerve conduction study (NCS) measures, consistent with standard clinical practice.
Potential confounders were identified.
NCS results were compared with historical controls, including unexposed workers matched by gender, age, and body mass index.
Dose-response relationships were evaluated using simple linear and stepwise regression models.
Three workers fulfilled clinical polyneuropathy criteria.
The only worker fulfilling NCS criteria for confirmed clinical polyneuropathy had diabetes mellitus.
Mean NCS values for most measures were similar to control values, and existing differences in sensory amplitudes disappeared when compared with the matched control group. (...)
Mots-clés Pascal : Solvant organique, Toxicité, Exposition professionnelle, Encéphalopathie, Polyneuropathie périphérique, Médecine travail, Homme, Association morbide, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie, Nerf périphérique pathologie
Mots-clés Pascal anglais : Organic solvent, Toxicity, Occupational exposure, Encephalopathy, Polyneuropathy, Occupational medicine, Human, Concomitant disease, Nervous system diseases, Central nervous system disease, Cerebral disorder, Peripheral nerve disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0355332
Code Inist : 002B03L04. Création : 14/12/1999.