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  1. Fulltext. Vertebral fractures and mortality in older women : A prospective study.

    Article - En anglais

    Fulltext.

    Background 

    Osteoporotic fractures, including clinically detected vertebral fractures, are associated with increased mortality.

    However, only one third of vertebral fractures are diagnosed.

    It is unknown whether vertebral fractures, whether clinically apparent or not, are associated with greater mortality.

    Objectives 

    To test the hypothesis that women with prevalent vertebral fractures have greater mortality than those without fractures and to describe causes of death associated with vertebral fractures.

    Design 

    Prospective cohort study with mean follow-up of 8.3 years.

    Setting 

    Four clinical centers in the United States.

    Participants 

    A total of 9575 women aged 65 years or older and enrolled in the Study of Osteoporotic Fractures.

    Measurements 

    Vertebral fractures by radiographic morphometry ; calcaneal bone mineral density ; demographic, medical history, and lifestyle variables ; blood pressure ; and anthropometric measures.

    In a subset of 606 participants, thoracic curvature was measured during a second clinic visit.

    Main Outcome Measures 

    Hazard ratios for mortality and cause-specific mortality.

    Results 

    At baseline, 1915 women (20.0%) were diagnosed as having vertebral fractures.

    Compared with women who did not have a vertebral fracture, women with 1 or more fractures had a 1.23-fold greater age-adjusted mortality rate (95% confidence interval, 1.10-1.37). (...)

    Mots-clés Pascal : Ostéoporose, Complication, Fracture, Vertèbre, Morbidité, Mortalité, Epidémiologie, Homme, Femelle, Système ostéoarticulaire pathologie, Ostéopathie, Traumatisme, Rachis pathologie

    Mots-clés Pascal anglais : Osteoporosis, Complication, Fracture, Vertebra, Morbidity, Mortality, Epidemiology, Human, Female, Diseases of the osteoarticular system, Bone disease, Trauma, Spine disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0353194

    Code Inist : 002B16H. Création : 14/12/1999.