Osteoporotic fractures, including clinically detected vertebral fractures, are associated with increased mortality.
However, only one third of vertebral fractures are diagnosed.
It is unknown whether vertebral fractures, whether clinically apparent or not, are associated with greater mortality.
To test the hypothesis that women with prevalent vertebral fractures have greater mortality than those without fractures and to describe causes of death associated with vertebral fractures.
Prospective cohort study with mean follow-up of 8.3 years.
Four clinical centers in the United States.
A total of 9575 women aged 65 years or older and enrolled in the Study of Osteoporotic Fractures.
Vertebral fractures by radiographic morphometry ; calcaneal bone mineral density ; demographic, medical history, and lifestyle variables ; blood pressure ; and anthropometric measures.
In a subset of 606 participants, thoracic curvature was measured during a second clinic visit.
Main Outcome Measures
Hazard ratios for mortality and cause-specific mortality.
At baseline, 1915 women (20.0%) were diagnosed as having vertebral fractures.
Compared with women who did not have a vertebral fracture, women with 1 or more fractures had a 1.23-fold greater age-adjusted mortality rate (95% confidence interval, 1.10-1.37). (...)
Mots-clés Pascal : Ostéoporose, Complication, Fracture, Vertèbre, Morbidité, Mortalité, Epidémiologie, Homme, Femelle, Système ostéoarticulaire pathologie, Ostéopathie, Traumatisme, Rachis pathologie
Mots-clés Pascal anglais : Osteoporosis, Complication, Fracture, Vertebra, Morbidity, Mortality, Epidemiology, Human, Female, Diseases of the osteoarticular system, Bone disease, Trauma, Spine disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0353194
Code Inist : 002B16H. Création : 14/12/1999.