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  1. Human T-cell lymphotropic virus type 1 infection and ocular manifestations in Sao Paulo, Brazil.

    Article - En anglais


    Although human T-cell lymphotropic virus type 1 (HTLV-1) - associated uveitis has been well recognized in Japan, related studies in Brazil are scarce.

    We performed a serologic survey for HTLV-infection among patients with uveitis and investigated the ocular findings in HTLV-1-asymptomatic carriers.


    One hundred ninety serum samples from patients with uveitis of determined (n=137) and undetermined origins (n=53) being examined at the Uveitis Service, University of Sao Paulo, Sao Paulo, Brazil, underwent testing using HTLV enzyme-linked immunosorbent assay and discriminatory Western blots.

    One hundred five asymptomatic blood donors and/or their relatives who were seropositive for HTLV-1 (carrier group) and 105 age-and sex-paired blood donors who were seronegative for HTLV-1 (control group) underwent ocular evaluation.

    For the statistical analysis, X2 test was used.


    Only 1 patient with uveitis was seropositive for HTLV-1, and she belonged to the group with uveitis of undetermined origin.

    Results of tear films were evaluated in 52 carriers.

    The prevalence ofa decreased tear break-up time was significantly higher in the carrier compared with the control group (P=02).

    Two carriers had keratoconjunctivitis sicca.

    Three of the 105 carriers exhibited mild uveitis (cells in the vitreous, retinal and choroidal infiltrates, retinal vasculitis, and bilateral pars planitis). (...)

    Mots-clés Pascal : Infection, Virus HTLV1, Retroviridae, Virus, Uvéite, Exploration, Film lacrymal, Brésil, Amérique du Sud, Amérique, Epidémiologie, Homme, Oeil pathologie, Uvée pathologie

    Mots-clés Pascal anglais : Infection, HTLV-I virus, Retroviridae, Virus, Uveitis, Exploration, Tear film, Brazil, South America, America, Epidemiology, Human, Eye disease, Uvea disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0351764

    Code Inist : 002B05C02B. Création : 14/12/1999.