Hepatitis C virus (HCV) is an emerging global public health issue with particular relevance in multiply transfused renal dialysis patients.
This cross-sectional study evaluated the prevalence and risk factors for HCV infection among renal dialysis patients in northern Alberta, Canada.
Ninety-two percent of eligible patients (n=336) provided informed consent to participate.
Participants were interviewed to gather risk factor information and, using multiple logistic regression analysis with exact inference, a predictive model for HCV infection in this population was developed.
The prevalence of HCV infection in the population was 6.5%, and all positive patients had at least one identifiable risk factor.
The multivariate analysis showed that the risk of HCV infection was greater for those in the 18-55 years age category (odds ratio (OR)=4.9,95% confidence interval (Cl) 1.2-27.9), patients who had been on dialysis>5 years (OR=3.7,95% Cl 1.2-12.0), and patients who had >=2 high risk life-style behaviors (OR=5.0,95% Cl 1.5-16.7).
Transfusion prior to 1990 was marginally associated with HCV status (OR=4.0,95% Cl 0.96-16.3).
This study documented previously unreported life-style risk factors for HCV infection in patients with renal failure, confirmed the expected decline in transfusion-acquired HCV infection in this population, and provided evidence against nosocomial transmission of HCV.
Mots-clés Pascal : Hépatite virale C, Virose, Infection, Hémodialyse, Epidémiologie, Prévalence, Facteur risque, Homme, Canada, Amérique du Nord, Amérique, Appareil digestif pathologie, Foie pathologie, Epuration extrarénale
Mots-clés Pascal anglais : Viral hepatitis C, Viral disease, Infection, Hemodialysis, Epidemiology, Prevalence, Risk factor, Human, Canada, North America, America, Digestive diseases, Hepatic disease, Extrarenal dialysis
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0350521
Code Inist : 002B05C02G. Création : 14/12/1999.