Risk of dementia in parents of probands with and without the apolipoprotein E4 allele. The EVA study.
Study objective-Age, family history of dementia and the epsilon4 allele of the apolipoprotein E gene have been associated with Alzheimer's disease (AD).
Considering the strength of APOE-epsilon4 as a genetic risk factor for AD, this factor might explain a large part of the association between AD and a family history of dementia.
Therefore, in the general population, a higher frequency of dementia should be observed among parents of probands with at least one epsilon4 allele than in parents of probands without this allele.
Design, setting, and participants-The study investigated a sample of 1153 volunteers between 59 and 71 years old, genotyped for the APOE gene, all participating in the EVA study.
Dementia in their parents was determined using a self reported questionnaire.
Main results-The frequency of dementia in 2164 parents was examined and it was found that 245 were demented.
The percentage of demented parents was 13.0% in the subgroup of parents of subjects having one or two epsilon4 alleles and 10.8% in the other subgroup.
The relative risk of dementia among parents according to the APOE-epsilon4 status of probands, was calculated using a Cox model adjusted for the educational level of parents and their history of stroke : RR=1.21 (95% CI 0.90,1.63).
Conclusion-This lack of association supports the observation that in the general population, APOE-epsilon4 cannot explain a large part of family history of dementia.
Mots-clés Pascal : Démence Alzheimer, Apolipoprotéine E, Allèle, Gène, Antécédent, Milieu familial, Age, Epidémiologie, Facteur risque, Génétique, Homme, France, Europe, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie, Maladie dégénérative
Mots-clés Pascal anglais : Alzheimer disease, Apolipoprotein E, Allele, Gene, Antecedent, Family environment, Age, Epidemiology, Risk factor, Genetics, Human, France, Europe, Nervous system diseases, Central nervous system disease, Cerebral disorder, Degenerative disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0349707
Code Inist : 002B17G. Création : 14/12/1999.