To evaluate if different levels of human herpesvirus 6 (HHV-6) antibodies can predict HIV disease progression.
Longitudinal study of individuals with a documented date of HIV seroconversion.
Clinical centers located throughout Italy.
Individuals who serconverted for HIV between 1983 and 1995 in Italy.
Sera were tested for IgG antibodies to HHV-6 using a commercial enzyme immunoassay.
A serum sample with an optical density (OD) >=242 (i.e. the mean value of 10 negative controls+4 x standard deviation) was considered as HHV-6 positive ; the progression of HIV disease was evaluated estimating the relative hazards (RH) of AIDS (by Cox models) for individuals with higher levels vs. lower levels of HHV-6 antibodies or considering levels of antibodies based on 10% increase of the distribution (deciles).
Rates of CD4 decline fitting linear regression were also estimated.
A total of 381 persons were followed for a median time of 4 years (range : 0.15-9 years) following the date of collection of the serum sample.
The median OD value of HHV-6 antibodies was 306, with an interquartile range of 241-440 and a range of 48-2330.
A slight inverse correlation was found between HHV-6 antibody levels and age of the individual at the time of serum collection (Spearman rank correlation coefficient, - 0.16 ; p=0.0013). (...)
Mots-clés Pascal : SIDA, Virose, Infection, Herpesvirus hominis 6, Herpesviridae, Virus, IgG, Anticorps, Plasma sanguin, Marqueur biologique, Epidémiologie, Taux, Evolution, Pronostic, Homme, Italie, Europe, Immunopathologie, Immunodéficit
Mots-clés Pascal anglais : AIDS, Viral disease, Infection, Herpesvirus hominis 6, Herpesviridae, Virus, IgG, Antibody, Blood plasma, Biological marker, Epidemiology, Rate, Evolution, Prognosis, Human, Italy, Europe, Immunopathology, Immune deficiency
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0349293
Code Inist : 002B05C02D. Création : 14/12/1999.