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  1. Serum IgG antibodies to human herpesvirus-6 (HHV-6) do not predict the progression of HIV disease to AIDS.

    Article - En anglais

    Objectives 

    To evaluate if different levels of human herpesvirus 6 (HHV-6) antibodies can predict HIV disease progression.

    Design 

    Longitudinal study of individuals with a documented date of HIV seroconversion.

    Setting 

    Clinical centers located throughout Italy.

    Patients 

    Individuals who serconverted for HIV between 1983 and 1995 in Italy.

    Methods 

    Sera were tested for IgG antibodies to HHV-6 using a commercial enzyme immunoassay.

    A serum sample with an optical density (OD) >=242 (i.e. the mean value of 10 negative controls+4 x standard deviation) was considered as HHV-6 positive ; the progression of HIV disease was evaluated estimating the relative hazards (RH) of AIDS (by Cox models) for individuals with higher levels vs. lower levels of HHV-6 antibodies or considering levels of antibodies based on 10% increase of the distribution (deciles).

    Rates of CD4 decline fitting linear regression were also estimated.

    Results 

    A total of 381 persons were followed for a median time of 4 years (range : 0.15-9 years) following the date of collection of the serum sample.

    The median OD value of HHV-6 antibodies was 306, with an interquartile range of 241-440 and a range of 48-2330.

    A slight inverse correlation was found between HHV-6 antibody levels and age of the individual at the time of serum collection (Spearman rank correlation coefficient, - 0.16 ; p=0.0013). (...)

    Mots-clés Pascal : SIDA, Virose, Infection, Herpesvirus hominis 6, Herpesviridae, Virus, IgG, Anticorps, Plasma sanguin, Marqueur biologique, Epidémiologie, Taux, Evolution, Pronostic, Homme, Italie, Europe, Immunopathologie, Immunodéficit

    Mots-clés Pascal anglais : AIDS, Viral disease, Infection, Herpesvirus hominis 6, Herpesviridae, Virus, IgG, Antibody, Blood plasma, Biological marker, Epidemiology, Rate, Evolution, Prognosis, Human, Italy, Europe, Immunopathology, Immune deficiency

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0349293

    Code Inist : 002B05C02D. Création : 14/12/1999.