The purpose of this study was to determine the effect of a fermented milk product containing Lactobacillus johnsonii Lal (formerly known as Lactobacillus acidophilus Lal) on the phagocytic activity of peripheral blood leukocytes in healthy adult volunteers.
Furthermore, we sought to define the effective doses of the bacteria, examine the effect on respiratory burst activity, and, finally, examine the contribution made by the starter culture to the biological effects.
Volunteers were randomly distributed among three groups ; each subject received one pot (150 ml) of fermented milk each day for 3 wk.
The first two groups received a freshly prepared product fermented by Streptococcus thermophilus (group A) alone or S. thermophilus and 107 cfu/ml L. johnsonii Lal (group B).
Group C received a product stored for a period of 21 to 28 d and that contained S. thermophilus and 106 cfu/ml of L. johnsonii La1.
Ingestion of L. johnsonii Lal did not significantly increase fecal lactobacilli counts.
However, L. johnsonii Lal was able to survive intestinal transit and was only recovered from the feces of the volunteers of groups B and C. The fermented base alone showed a weak effect on respiratory burst but not on phagocytic activity.
However, the product containing 107 cfu/ml L. johnsonii Lal significantly enhanced both functions.
The product containing 106 cfu/ml of L. johnsonii Lal had no significant effect on either function. (...)
Mots-clés Pascal : Etude expérimentale, Adulte, Homme, Leucocyte, Phagocyte, Lait fermenté, Probiotique, Effet biologique, Mécanisme défense, Immunomodulation, Relation dose réponse, Produit laitier, Aliment santé, Bactérie lactique, Lactobacillus acidophilus, Lactobacillaceae, Bactérie, Streptococcus A, Streptococcaceae, Micrococcales, Streptococcus salivarius subsp. thermophilus, Phagocytose, Respiration cellulaire, Emballement respiratoire, Dose efficace
Mots-clés Pascal anglais : Experimental study, Adult, Human, Leukocyte, Phagocyte, Cultured milk, Probiotic, Biological effect, Defense mechanism, Immunomodulation, Dose activity relation, Dairy product, Health food, Lactic acid bacteria, Lactobacillus acidophilus, Lactobacillaceae, Bacteria, Streptococcus A, Streptococcaceae, Micrococcales, Streptococcus salivarius subsp. thermophilus, Phagocytosis, Cell respiration, Respiratory burst, Effective dose
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0347853
Code Inist : 002A35B04. Création : 14/12/1999.