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  1. Fulltext. Adjunctive therapy in sepsis : a critical analysis of the clinical trial programme.

    Article - En anglais


    Despite intensive efforts, the development of novel drugs for the treatment of sepsis has proved to be extremely difficult.

    A large number of clinical trials have ended in failure.

    A critical analysis of this record suggests that there is no single reason for these problems.

    Rather, the explanation lies in part with unexpected failures in the drugs themselves, and in part with the difficulties of trial design in this particular group of patients.

    In future, trials in this area are likely to be more highly focused, with even stricter protocol definitions to try and ensure a homogeneous patient population.

    Mots-clés Pascal : Septique syndrome, Infection, Protocole thérapeutique, Evaluation, Traitement adjuvant, Arbre décision, Etude comparative, Programme application, Article synthèse, Homme, Réanimation, Chimiothérapie, Organisation santé

    Mots-clés Pascal anglais : Sepsis syndrome, Infection, Therapeutic protocol, Evaluation, Adjuvant treatment, Decision tree, Comparative study, Application program, Review, Human, Resuscitation, Chemotherapy, Public health organization

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0346557

    Code Inist : 002B27B10. Création : 14/12/1999.