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  1. Prevalence and predictors of depressive symptoms in older premenopausal women : The Harvard Study of Moods and cycles.

    Article - En anglais


    The Harvard Study of Moods and Cycles is a community-based cohort study designed to evaluate the relationship between major depression and changes in menstrual and ovarian function.


    All women aged 36 to 44 years with a verifiable address from 7 Boston, Mass, metropolitan communities were selected from the Massachusetts Town Books.

    A self-administered questionnaire assessed demographic characteristics and menstrual history, depression history, and current depressive symptoms (Center for Epidemiologic Studies Depression Scale [CES-D]) in 4161 women.


    We observed a score of 16 or more on the CES-D in 22.4% of women surveyed, and 8.6% scored 25 or more.

    Widowed, divorced, or separated women were twice as likely as married women to have depression scores greater than 16 (95% confidence interval, 1.6-2.8), and smokers in the upper tertile of pack-years were 1.9 times more likely to have CES-D scores of 16 or more (95% confidence interval, 1.5-2.3).

    Relative to nulliparous women, those with 1 or 2 children had a 30% lower risk of historic mood disorder, and those with 3 or more children had an even greater reduction in risk (odds ratio, 0.4 ; 95% confidence interval, 0.3-0.6).

    Menstrual cycle irregularities were largely unassociated with current or past depression.

    However, 5 of 8 premenstrual symptoms were significantly associated with CES-D scores of 16 or more. (...)

    Mots-clés Pascal : Etat dépressif, Facteur risque, Homme, Femelle, Préménopause, Prévalence, Massachusetts, Etats Unis, Amérique du Nord, Amérique, Epidémiologie, Santé mentale, Cycle menstruel, Trouble humeur

    Mots-clés Pascal anglais : Depression, Risk factor, Human, Female, Premenopause, Prevalence, Massachusetts, United States, North America, America, Epidemiology, Mental health, Menstrual cycle, Mood disorder

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0346370

    Code Inist : 002B18C07A. Création : 14/12/1999.