The association between depressive disorders and subsequent cognitive decline is controversial.
We tested the hypothesis that elderly women (aged 65 years and older) without dementia but with depressive symptoms have worse cognitive function and greater cognitive decline than women with few or no symptoms.
As part of an ongoing prospective study, we evaluated 5781 elderly, mostly white, community-dwelling women.
Women completed the Geriatric Depression Scale short form.
Three cognitive tests-Trails B, Digit Symbol, and a modified Mini-Mental State Examination-were administered at baseline and approximately 4 years later.
Baseline, follow-up, and change scores for the cognitive tests were analyzed by analysis of covariance and Kruskal-Wallis analysis ; the odds of cognitive deterioration (>=3-point decline on the modified Mini-Mental State Examination) were determined by logistic regression.
At baseline, 211 (3.6%) of the women had 6 or more depressive symptoms.
Only 16 (7.6%) of these women were receiving antidepressant medication.
Increasing symptoms of depression were associated with worse performance at baseline and follow-up on all 3 tests of cognitive function (P<. 001 for all comparisons).
For example, the baseline Digit Symbol score (mean ±SD) was 45.5 ± 10.7 among women with 0 to 2 symptoms of depression, 40.3 ± 10.7 for women with 3 to 5 symptoms, and 39.0 ± 11.3 for women with 6 or more symptoms. (...)
Mots-clés Pascal : Etat dépressif, Symptomatologie, Détérioration intellectuelle, Trouble cognition, Prévalence, Epidémiologie, Etats Unis, Amérique du Nord, Amérique, Santé mentale, Personne âgée, Homme, Femelle, Trouble humeur
Mots-clés Pascal anglais : Depression, Symptomatology, Intellectual deterioration, Cognitive disorder, Prevalence, Epidemiology, United States, North America, America, Mental health, Elderly, Human, Female, Mood disorder
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0346192
Code Inist : 002B18E. Création : 14/12/1999.