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  1. Pamidronate for the prevention of skeletal-related events in multiple myeloma : what does the public think it is worth ?

    Article - En anglais

    Multiple myeloma is a disorder of the bone marrow that is associated with bone pain and osteolytic lesions.

    These complications can lead to the development of pathologic fractures and severe patient morbidity.

    However, the results of a recent randomized trial in patients with multiple myeloma demonstrated that single 90 mg monthly doses of pamidronate as an adjunct to chemotherapy reduced the incidence of skeletal-related events and improved patients'quality of life.

    A cost-benefit analysis using an ex-ante insurance willingness-to-pay (WTP) approach was conducted from a Canadian societal perspective to estimate the net cost or benefit of prophylactic pamidronate therapy for patients with multiple myeloma.

    This included direct costs for drug administration and hospital savings secondary to avoiding skeletal-related events.

    One hundred Canadian taxpayers were then interviewed to ascertain their maximum WTP for the benefits of pamidronate.

    The WTP survey instrument was simple to administer and easily understood by participants.

    Respondents stated that they would be willing to pay an average of Can $3,364 (95% Cl : $2,096. $4,632) as an income tax increase to be paid over their lifetime for the value offered by the product.

    The benefit was then subtracted from the overall cost of nine monthly doses of pamidronate ($4,153) producing a net societal cost of $789 per patient (95% Cl : $479, $2,057). (...)

    Mots-clés Pascal : Acide pamidronique, Traitement adjuvant, Indication, Myélome, Chimiothérapie, Prévention, Analyse avantage coût, Fracture pathologique, Os, Etude statistique, Economie santé, Essai clinique, Diphosphonique acide dérivé, Bisphosphonates, Hémopathie maligne, Lymphoprolifératif syndrome, Immunopathologie, Immunoglobulinopathie, Système ostéoarticulaire pathologie, Traumatisme, Antihypercalcémiant

    Mots-clés Pascal anglais : Pamidronic acid, Adjuvant treatment, Indication, Myeloma, Chemotherapy, Prevention, Cost benefit analysis, Pathologic fracture, Bone, Statistical study, Health economy, Clinical trial, Diphosphonic acid derivatives, Bisphosphonates, Malignant hemopathy, Lymphoproliferative syndrome, Immunopathology, Immunoglobulinopathy, Diseases of the osteoarticular system, Trauma

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0343964

    Code Inist : 002B02D. Création : 14/12/1999.