OBJECTIVE To determine the prevalence of mucocutaneous conditions and their association with HIV-1 infection in a rural community in Uganda.
METHODS In a prospective cohort study, participants were recruited from a large population study and invited to attend a clinic every 3 months for a detailed medical interview and a thorough physical examination.
All findings including mucocutaneous findings were coded onto a standard questionnaire.
RESULTS By the end of 1996,436 participants had provided 1450 person years of observation (pyo) ; 646 pyo in HIV-positives and 804 pyo in HIV-negatives.
Overall, 70% of participants had a skin condition during follow-up, and although skin conditions were significantly more common in HIV-positive subjects, the background level in HIV-negative subjects was high (77.3% and 63.6%, respectively).
Herpes zoster, thin/sparse hair, maculo-papular rash and prurigo were significantly more common in the HIV-positives.
Kaposi sarcoma, palmar/plantar rash and herpes zoster had positive predictive values for HIV infection of over 80%. Oral conditions were found in over 40% of participants and were significantly more common in HIV-positive subjects.
Oral candidiasis and Kaposi sarcoma were significantly more frequent among HIV-positives.
CONCLUSION HIV infection increases the already high burden of mucocutaneous diseases in this rural population. (...)
Mots-clés Pascal : SIDA, Virose, Infection, Virus HIV1, Virus immunodéficience humaine, Lentivirus, Retroviridae, Virus, Asymptomatique, Cutanéomuqueux, Lésion, Prévalence, Association, Ouganda, Afrique, Homme, Immunopathologie, Immunodéficit, Peau pathologie
Mots-clés Pascal anglais : AIDS, Viral disease, Infection, HIV-1 virus, Human immunodeficiency virus, Lentivirus, Retroviridae, Virus, Asymptomatic, Mucocutaneous, Lesion, Prevalence, Association, Uganda, Africa, Human, Immunopathology, Immune deficiency, Skin disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0343917
Code Inist : 002B05C02D. Création : 14/12/1999.