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  1. New evidence to reconcile in vitro and epidemiologic data on the possible role of heroin on CD4+decline among HIV-infected injecting drug users.

    Article - En anglais

    Long-term effects of drug type and other drug use related risk factors on CD4+cell decline were assessed in 224 HIV-infected injecting drug users (IDUs) from Baltimore (ALIVE), USA, and 63 IDUs from Amsterdam.

    The Netherlands.

    Higher frequencies of borrowing used injection equipment since 1980 resulted in a higher CD4+count already present before seroconversion (P=0.049).

    Use of mainly heroin in the seroconversion interval resulted in a sharper CD4+decline until the first 6 months after seroconversion (P=0.004), but CD4+values converged later on.

    This finding might reconcile earlier discordant epidemiological and laboratory study results regarding the possible effects of heroin.

    Mots-clés Pascal : SIDA, Virose, Infection, Virus immunodéficience humaine, Lentivirus, Retroviridae, Virus, Lymphocyte T, Sous population cellulaire, Immunité cellulaire, Dépendance, Héroïne, Drogue illicite, Toxicomanie, Epidémiologie, Facteur risque, Homme, Immunopathologie, Immunodéficit, Antigène CD4

    Mots-clés Pascal anglais : AIDS, Viral disease, Infection, Human immunodeficiency virus, Lentivirus, Retroviridae, Virus, T-Lymphocyte, Cell subpopulation, Cellular immunity, Dependence, Heroin, Illicit drug, Drug addiction, Epidemiology, Risk factor, Human, Immunopathology, Immune deficiency

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0343557

    Code Inist : 002B05C02D. Création : 14/12/1999.