Geographical variation in disease progression in HIV-1 seroconverted injecting drug users in europe ?
Background Human immunodeficiency virus (HIV) disease progression might vary by geographical region due to differences in the spectrum of HIV-related illnesses and (access to) health care.
Therefore, the effect of geographical region, next to the effect of other potential cofactors, on disease progression in 664 injecting drug users (IDU) with documented HIV seroconversion from eight cohorts in Europe was studied.
Methods Kaplan-Meier methods and Cox proportional hazards analysis were performed to assess the effect of geographical region, other sociodemographics, drug use and repeated HIV exposure on progression from HIV seroconversion to immunosuppression, AIDS and death with AIDS.
We considered the confounding effect of study-design related factors (e.g. setting of follow-up), and accounted for pre-AIDS death from natural causes by imputing when each endpoint would have occurred, had they not died without AIDS.
Results Estimates of progression to AIDS and death with AIDS were substantially faster after taking pre-AIDS mortality into account.
Median incubation time from seroconversion to the first CD4 count<200 cells/mul was 7.7 years (95% CI : 7.1-8.3) and to AIDS 10.4 years (95% CI : 9.8-).
The 10-year survival was 70.3% (95% CI : 62.8-76.6).
The relative hazards (RH) of AIDS for IDU from central and southern Europe compared with IDU from northern Europe was 1.9 (95% CI : 1.2-3.0) and 1.2 (95% CI : 0.6-2.3), respectively, before, and 1.5 (95% CI : 0.7-3.2) and 1. (...)
Mots-clés Pascal : SIDA, Virose, Infection, Toxicomanie, Variation géographique, Epidémiologie, Mortalité, Prévalence, Evolution, Homme, Europe, Immunopathologie, Immunodéficit
Mots-clés Pascal anglais : AIDS, Viral disease, Infection, Drug addiction, Geographical variation, Epidemiology, Mortality, Prevalence, Evolution, Human, Europe, Immunopathology, Immune deficiency
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0341732
Code Inist : 002B05C02D. Création : 14/12/1999.