Greater sensitivity to ionizing radiation at older age : follow-up of workers at Oak Ridge National Laboratory through 1990.
Background Workers at Oak Ridge National Laboratory (ORNL) were individually monitored for whole body exposure to ionizing radiation.
Studies of these workers may provide valuable information about the long-term effects of occupational exposure to ionizing radiation.
Since biological changes occur as adults age, a potentially important question in these investigations is whether sensitivity to the carcinogenic effects of ionizing radiation changes with age at exposure.
Methods Vital status and cause of death were ascertained through 1990 for 8307 white males hired at ORNL from 1943 through 1972.
Associations between whole body ionizing radiation dose and all-cancer mortality were quantified using life table regression methods for time dependent exposures.
Analyses focused of differences in radiation-cancer associations with age at exposure.
Length of follow-up, period of hire, and age at risk were considered as alternative explanations for effects of age at exposure.
Results Cumulative radiation dose was associated with a 1.8% (SE=0.9) increase in all-cancer mortality per 10 mSv, assuming a 10-year lag between exposure and mortality.
However, radiation doses received at older ages exhibited larger associations with cancer mortality than doses received at younger ages.
Doses received after age 45 were associated with a 5.9% (SE=1.7) increase in cancer mortality per 10 mSv, adjusted for doses received before age 45. (...)
Mots-clés Pascal : Tumeur maligne, Exposition professionnelle, Rayonnement ionisant, Epidémiologie, Facteur risque, Personne âgée, Homme, Médecine travail, Etats Unis, Amérique du Nord, Amérique
Mots-clés Pascal anglais : Malignant tumor, Occupational exposure, Ionizing radiation, Epidemiology, Risk factor, Elderly, Human, Occupational medicine, United States, North America, America
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0341638
Code Inist : 002B04B. Création : 14/12/1999.