Plasma vitamin C levels in men and women from different ethnic backgrounds living in England.
Background People of South Asian origin living in the UK have higher death rates due to coronary heart disease than whites.
The reasons for these differences are not fully understood.
Previous attempts to relate diet to cardiovascular risk in South Asians have been inconclusive.
Methods We compared the levels of plasma vitamin C in a cross-sectional population-based study of 1018 men and women aged 40-59 (455 men, 563 women, 328 South Asians, 355 of African descent, 335 whites) co-resident in a geographically defined area of South London, when allowing for potential confounders.
Results Fasting plasma vitamin C levels were significantly higher in women, vegetarians, supplement takers and non-smokers.
After adjustment for age, body mass index, current smoking, supplement use and vegetarianism the mean plasma vitamin C levels were 38.8 (SE 1.6) mumol/l in white men, 36. 5 (1.6) mumol/l in men of African descent and 32.9 (1.5) mumol/l in South Asian men (P=0.033 by analysis of covariance).
In women the adjusted mean plasma vitamin C levels were 52.4 (1.6) mumol/l in whites, 46.0 (1.4) mumol/l in women of African descent and 37.3 (1.8) mumol/l in South Asians (P<0.0001 by analysis of covariance).
South Asians had lower levels than whites in both men (difference 6.4 [95% CI : 1.5,11.3] mumol/l) and women (16.8 [95% CI : 11.5,22.1] mumol/l).
South Asian women, but not men, also had lower levels than those of African descent (8.8 [95% CI : 4.5,13.1] mumol/l). (...)
Mots-clés Pascal : Cardiopathie coronaire, Facteur risque, Régime alimentaire, Acide ascorbique, Plasma sanguin, Ethnie, Antioxydant, Epidémiologie, Taux, Mesure, Homme, Angleterre, Grande Bretagne, Royaume Uni, Europe, Appareil circulatoire pathologie
Mots-clés Pascal anglais : Coronary heart disease, Risk factor, Diet, Ascorbic acid, Blood plasma, Ethnic group, Antioxidant, Epidemiology, Rate, Measurement, Human, England, Great Britain, United Kingdom, Europe, Cardiovascular disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0340745
Code Inist : 002B30A02A. Création : 14/12/1999.