Background Most HIV-infection in children occurs in sub-Saharan Africa where antiretroviral therapy is seldom available.
This study compares the growth progression and retardation of HIV-infected and uninfected children in the Democratic Republic of Congo (formerly Zaire).
It estimates the risk for child growth retardation according to child and maternal immunological factors, severity of maternal and child illness, and maternal socioeconomic and marital status.
Methods In a prospective cohort study of 258 children born to HIV seropositive mothers and 256 children of seronegative mothers in Kinshasa, Congo, the growth in length, weight, and weight-for-length of infected children (n=68), uninfected children born to seropositive mothers (n=190), and uninfected children born to uninfected mothers (n=256) was compared.
Serological, anthropometric and other clinical measures were collected monthly from 3-12 months and bi-monthly during the second year of life.
Polymerase chain reaction for HIV was performed on bloods drawn at 2 days and 3 months post partum.
Length-for-age, weight-for-age, and weight-for-length mean z-scores against National Center for Health Statistics (NCHS) reference data were calculated, and Cox proportional hazards models were used to estimate the risk of falling below - 2.00 z-scores as a function of child and maternal immunological, clinical and sociodemographic variables. (...)
Mots-clés Pascal : SIDA, Virose, Infection, Biométrie corporelle, Croissance, Mère, Facteur risque, Nourrisson, Homme, Femelle, Epidémiologie, Congo Brazzaville, Afrique, Congo(République démocratique), Immunopathologie, Immunodéficit
Mots-clés Pascal anglais : AIDS, Viral disease, Infection, Corporal biometry, Growth, Mother, Risk factor, Infant, Human, Female, Epidemiology, Congo, Africa, Congo(Democratic republic), Immunopathology, Immune deficiency
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0340623
Code Inist : 002B05C02D. Création : 14/12/1999.