The standard mouse bioassay was used for obtaining the RD50 (i.e., the concentration that causes a 50% decrease in respiratory frequency) and for estimating the irritation properties of d-delta3-carene (i.e., (+) - delta3-carene) and commercial turpentine.
The chemicals studied possess mainly sensory irritation properties similar to the previously studied monoterpenes, pinenes.
The irritation potency of d-delta3-carene (RD50=1345 ppm) was almost equal to that of d-pinenes.
Thus, d-delta3-carene was about four times more potent as a sensory irritant than 1-bêta-pinene, whereas the difference with 1-alpha-pinene was more marked ; as a sensory irritant, 1-alpha-pinene is almost inactive.
Based on sensory irritation potency and physicochemical and structural properties of pinenes and delta3-carene, the potency of a closely related monoterpene, limonene, is discussed.
For commercial turpentine, a mixture of monoterpenes (mainly d-delta3-carene, 1-bêta-pinenes, alpha-pinenes, and limonenes), the RD50 (1173 ppm) was the same order of magnitude as those of d-pinenes and d-delta3-carene.
Apparently, d-monoterpenes are responsible for the sensory irritation caused by turpentine.
In the wood industry and in the indoor air of nonindustrial environments, monoterpenes are thought to be one of the causative agents for irritation symptoms. (...)
Mots-clés Pascal : Evaluation risque, Toxicité, Monoterpène, Terpène, Hydrocarbure, Pinène, p-Mentha-1,8-diène, Térébenthine, Irritation, Appareil respiratoire pathologie, Système nerveux pathologie, Inhalation, Pollution air, Pollution intérieur, Exposition professionnelle, Médecine travail, Homme, Animal, Relation structure activité, Relation dose réponse, Car-2-ène
Mots-clés Pascal anglais : Risk assessment, Toxicity, Monoterpene, Terpene, Hydrocarbon, Pinene, 1,8-p-Menthadiene, Turpentine, Irritation, Respiratory disease, Nervous system diseases, Inhalation, Air pollution, Indoor pollution, Occupational exposure, Occupational medicine, Human, Animal, Structure activity relation, Dose activity relation
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0340196
Code Inist : 002B03L06. Création : 14/12/1999.