To develop an analytical approach for estimating the lifetime costs of rheumatoid arthritis (RA) using existing population based cross sectional data, and to use this estimate to describe the potential cost-effectiveness of bone marrow transplantation for RA.
Estimates of arthritis related costs (direct, indirect, and nonmedical) and mortality were obtained from previously assembled population based cohorts.
A mathematical model was designed defining 25 hypothetical ratios (RA/NA) representing the proportionate excess cost of RA each year for the 25 years following a diagnosis of RA.
Using age and sex-specific cost estimates, we then simulated a vector of 25 ratios 1000 times.
Each age and sex-specific randomly generated variable was converted to an estimated dollar amount (in 1995 dollars US) of excess cost attributable to RA.
All dollar amounts were discounted by 3% per year.
Finally, each vector of 25 discounted dollar amounts was summed to yield an estimate of the total excess medical costs in 1995 dollars for the first 25 years of a person's lifetime following a diagnosis of RA. (...)
Mots-clés Pascal : Polyarthrite rhumatoïde, Traitement, Homme, Greffe, Moelle osseuse, Analyse coût efficacité, Epidémiologie, Méthode analytique, Modèle mathématique, Chronique, Système ostéoarticulaire pathologie, Rhumatisme inflammatoire, Immunopathologie, Maladie autoimmune, Chirurgie orthopédique
Mots-clés Pascal anglais : Rheumatoid arthritis, Treatment, Human, Graft, Bone marrow, Cost efficiency analysis, Epidemiology, Analytical method, Mathematical model, Chronic, Diseases of the osteoarticular system, Inflammatory joint disease, Immunopathology, Autoimmune disease, Orthopedic surgery
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0339970
Code Inist : 002B28B. Création : 14/12/1999.