Background The large differences in cardiovascular disease rates between Eastern and Western Europe have largely developed over the last few decades, and are only partly explained by classical risk factors.
This study was set up to identify other potential determinants of these differences.
Methods This was an ecological study comparing random samples of men aged 45-64 years selected from three cities representing populations with different rates of cardiovascular mortality : Pardubice (Czech Republic), Augsburg (Bavaria, Germany), and Jerusalem (Israel).
In total, 191 (response rate 70%), 153 (70%) and 162 (62%) men, respectively, participated.
All centres followed the same study protocol.
Lifestyle, anthropometry and biochemical risk factors were assessed by identical questionnaires, standardized medical examination, and central analyses of fasting blood samples.
Results The mortality rates in the study populations, as well as the prevalence of coronary heart disease in study samples, were highest in Czech, intermediate in Bavarian and low in Israeli men.
This pattern was replicated across the three samples by mean blood pressure (P<0.001), cigarette smoking (not significant), triglycerides (P<0.05), fibrinogen or D-dimer levels (P<0.05). (...)
Mots-clés Pascal : Cardiopathie coronaire, Répartition géographique, Israël, Asie, Tchèque, Bavière, Allemagne, Europe, Homocystéine, Lipide, Insuline, Glycémie, Facteur coagulation, Caroténoïde, Epidémiologie, Facteur risque, Homme, Etude multicentrique, Etude comparative, Appareil circulatoire pathologie
Mots-clés Pascal anglais : Coronary heart disease, Geographic distribution, Israel, Asia, Czech, Bavaria, Germany, Europe, Lipids, Insulin, Glycemia, Coagulation factor, Carotenoid, Epidemiology, Risk factor, Human, Multicenter study, Comparative study, Cardiovascular disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0339925
Code Inist : 002B12A03. Création : 14/12/1999.