The presence of IgE-mediated occupational respiratory sensitization to microbial enzymes has been well documented in a variety of industries.
Aspergillus oryzae-derived lactase is used as a dietary aid for patients with lactose intolerance.
In 1993, a cross-sectional survey of 94 pharmaceutical workers exposed to lactase for a mean duration of 23 months and 24 nonexposed recently hired employees was initiated to identify lactase-sensitized workers and potential risk factors that could be used in making recommendations for preventing future cases of lactase sensitization.
The survey included a physician-administered questionnaire, skin prick testing to lactase enzyme and a panel of common aeroallergens, and spirometry.
Twenty-seven of 94 lactase-exposed workers (29%) had positive skin test responses to lactase.
These workers were 9 times more likely to have upper or lower respiratory symptoms compared with workers with negative skin test responses.
Atopic workers were 4 times more likely to have lactase skin sensitivity than nonatopic workers.
However, atopy was not a risk factor for the development of upper and/or lower respiratory symptoms.
Lactase skin reactivity was not observed in the 24 nonexposed employees. (...)
Mots-clés Pascal : Industrie pharmaceutique, Exposition professionnelle, Aspergillus oryzae, Fungi Imperfecti, Fungi, Thallophyta, Facteur risque, Allergie, Etude transversale, Appareil respiratoire pathologie, Etude cohorte, Lactase, O-Glycosidases, Glycosidases, Hydrolases, Enzyme, Sensibilisation, Origine microbienne, Protéine, Médecine travail, Immunopathologie
Mots-clés Pascal anglais : Pharmaceutical industry, Occupational exposure, Aspergillus oryzae, Fungi Imperfecti, Fungi, Thallophyta, Risk factor, Allergy, Cross sectional study, Respiratory disease, Cohort study, Lactase, O-Glycosidases, Glycosidases, Hydrolases, Enzyme, Sensitization, Microbial origin, Protein, Occupational medicine, Immunopathology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0338595
Code Inist : 002B05C04. Création : 14/12/1999.