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  1. Ethical aspects of clinical trials : the attitudes of the public and out-patients.

    Article - En anglais

    Objectives

    To investigate attitudes to clinical research amongst potential research participants.

    Design

    Questionnaire-survey.

    Setting

    Two medical out-patient clinics and the background population.

    Subjects

    A total of 508 randomly selected citizens in Copenhagen County (64% responded) and 200 consecutive patients attending the out-patient clinics (64% responded).

    Outcome measures

    Attitudes toward different aspects of clinical research.

    Results

    Positive attitudes toward medical research were disclosed.

    The majority found scientific testing necessary, although only a minority considered participation a moral obligation.

    Both personal benefits and altruistic motives for participation were highly rated, whereas former positive experiences from trial participation had only minor impact on decisions.

    Several respondents stated former trial participation had changed their attitudes negatively.

    Lack of feedback of results was of major importance for this change.

    Attitudes are significantly influenced by the presence of independent research ethics committees, whereas trial technicalities such as drawing lots and blinding was found problematic by only a few respondents.

    Altruistic motives of physicians to conduct trials were highly rated by a majority of respondents, but the motive of promoting doctors'careers was also judged important.

    Respondents rated nondiscomforting procedures as acceptable or having only a small impact or strain on their, lives. (...)

    Mots-clés Pascal : Essai clinique, Ethique, Attitude, Population, Observation, Questionnaire, Enquête, Homme

    Mots-clés Pascal anglais : Clinical trial, Ethics, Attitude, Population, Observation, Questionnaire, Survey, Human

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0335829

    Code Inist : 002B30A09. Création : 16/11/1999.