Bronchogenic carcinoma in Young patients.
Background and Objectives
Some investigators have suggested that lung cancer in young patients has a more aggressive course and poorer prognosis than lung cancer in older patients.
A retrospective review is presented of patients less than 40 years of age with bronchogenic carcinoma treated at Roswell Park Cancer Institute between 1984 and 1994, with comparison to a cohort of patients treated in the previous decade.
There were 76 patients (41 male and 35 female).
Mean age was 35 years (range, 26-39).
Adenocarcinoma in 33 patients (43%) and undifferentiated large-cell carcinoma in 22 patients (29%) were the predominant histologic types.
Stage IIIa or greater disease was present in 63 (83%) patients.
Treatment consisted of chemotherapy (55 patients), radiation therapy (54 patients), and surgery (33 patients).
Surgical procedures included pneumonectomy (14 patients), lobectomy (11 patients), wedge resection (1 patient), and thoracotomy only for unresectable disease (7 patients).
Operative mortality was 6% (two patients who had radical pneumonectomy for T4 cancer).
Median survival for the entire group of patients was 10.4 months, and 5-year survival was 8%. Univariate analysis identified acute presentation (P=0.02), no resection (P=0.0001), and higher stage (P=0.0001) as negative prognostic factors.
On multivariate analysis, stage of disease was the only independent predictor of survival (P=0.005).
Resectability was slightly higher (34%, 26/76, vs. (...)
Mots-clés Pascal : Carcinome, Bronchopulmonaire, Epidémiologie, Survie, Pronostic, Etude longitudinale, Adulte jeune, Homme, Critère âge, Evaluation, Appareil respiratoire pathologie, Poumon pathologie, Bronche pathologie, Tumeur maligne, Cancer bronchogénique
Mots-clés Pascal anglais : Carcinoma, Bronchopulmonary, Epidemiology, Survival, Prognosis, Follow up study, Young adult, Human, Age criterion, Evaluation, Respiratory disease, Lung disease, Bronchus disease, Malignant tumor
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0334492
Code Inist : 002B11A. Création : 16/11/1999.