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  1. The potential use of heat-shock proteins to vaccinate against mycobacterial infections.

    Article - En anglais

    Over the last few years, some of our experiments in which mycobacterial heat-shock protein (HSP) antigens were presented to the immune system as if they were viral antigens have had a significant impact on our understanding of protective immunity against tuberculosis.

    They have also markedly enhanced the prospects for new vaccines.

    We now know that the mycobacterial HSP65 antigen can confer protection equal to that from live BCG vaccine in mice.

    Mots-clés Pascal : Mycobacterium tuberculosis, Mycobacteriaceae, Mycobacteriales, Actinomycetes, Bactérie, Homme, Tuberculose, Mycobactériose, Bactériose, Infection, Vaccin, Recherche développement, Antigène, Protéine choc thermique, Plasmide, Vecteur, Adjuvant immunologique, Relation formulation propriété, Immunogénicité, Evaluation performance, Article synthèse

    Mots-clés Pascal anglais : Mycobacterium tuberculosis, Mycobacteriaceae, Mycobacteriales, Actinomycetes, Bacteria, Human, Tuberculosis, Mycobacterial infection, Bacteriosis, Infection, Vaccine, Research and development, Antigen, Heat shock protein, Plasmid, Vector, Immunological adjuvant, Property formulation relationship, Immunogenicity, Performance evaluation, Review

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0333187

    Code Inist : 002A05B12. Création : 16/11/1999.