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  1. Frequency of the fragile X syndrome in Chinese mentally retarded populations is similar to that in Caucasians.

    Article - En anglais

    Fragile X syndrome is recognized as the most common inherited cause of mental retardation in western countries.

    The prevalence of the fragile X syndrome in Asian populations is uncertain.

    We report a multiinstitutional collaborative study of molecular screening for the fragile X syndrome from 1,127 Chinese mentally retarded (MR) individuals.

    We found that 2.8% of the Chinese MR population screened by DNA analysis had the fragile X full mutation.

    Our screening indicated that the fragile X syndrome prevalence was very close to that of Caucasian subjects.

    In addition, we found that 62.5% of fragile X chromosomes had a single haplotype for DXS548-FRAXAC1 (21-18 repeats) which was present in only 9.7% of controls.

    This unique distribution of microsatellite markers flanking the FMR1 CGG repeats suggests that the fragile X syndrome in Chinese populations, as in the Caucasian, may also be derived from founder chromosomes.

    Mots-clés Pascal : X fragile syndrome, Chinois, Chine, Asie, Epidémiologie, Etude comparative, Déficience intellectuelle, Caucasoïde, Effet fondateur, Prévalence, Fragilité chromosomique, Maladie héréditaire

    Mots-clés Pascal anglais : Fragile X syndrome, Chinese, China, Asia, Epidemiology, Comparative study, Intellectual deficiency, Caucasoid, Founder effect, Prevalence, Chromosome fragility, Genetic disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0330031

    Code Inist : 002B23C. Création : 16/11/1999.