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  1. Larger increases in bone mineral density during alendronate therapy are associated with a lower risk of new vertebral fractures in women with postmenopausal osteoporosis.

    Article - En anglais

    Objective

    To investigate whether the incidence of vertebral fractures is related to the magnitude of change in bone mineral density (BMD) during alendronate treatment.

    Methods

    Women in this study were age 55-81 years (n=2,984).

    While participating in the Fracture Intervention Trial, they received 5 mg/day of alendronate for 2 years followed by 10 mg/day for the remaining 12-30 months of the study.

    Their BMD was measured at baseline and at 12 and 24 months, and spine radiographs were obtained at baseline and again at 36 or 48 months to identify new vertebral fractures.

    Results

    After 12 months of alendronate treatment, 35% of participants had increases of >=3% in total hip BMD, and 21% had either decreased total hip BMD or no change.

    Women who had larger increases in total hip BMD during the first 12 months had a lower incidence of new vertebral fractures during the entire followup period.

    Only 3.2% of women with increases of >=3% in total hip BMD experienced new vertebral fractures, whereas twice as many women (6.3%) whose BMD declined or stayed the same experienced new fractures (adjusted odds ratio 0.45,95% confidence interval 0.27-0.72).

    Similar patterns were observed for spine BMD at 12 months, and for both sites using change in BMD at 24 months.

    Conclusion

    Women with increases of >=3% in BMD during the first 1 or 2 years of alendronate treatment had the lowest incidence of new vertebral fractures. (...)

    Mots-clés Pascal : Ostéoporose, Association, Postménopause, Acide alendronique, Traitement, Prévention, Fracture, Densité, Os, Epidémiologie, Incidence, Facteur risque, Femelle, Personne âgée, Homme, Chimiothérapie, Diphosphonique acide dérivé, Bisphosphonates, Vertèbre, Système ostéoarticulaire pathologie, Ostéopathie, Traumatisme, Rachis pathologie

    Mots-clés Pascal anglais : Osteoporosis, Association, Postmenopause, Alendronic acid, Treatment, Prevention, Fracture, Density, Bone, Epidemiology, Incidence, Risk factor, Female, Elderly, Human, Chemotherapy, Diphosphonic acid derivatives, Bisphosphonates, Vertebra, Diseases of the osteoarticular system, Bone disease, Trauma, Spine disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0329780

    Code Inist : 002B02L. Création : 16/11/1999.