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  1. Is fasting glucose sufficient to define diabetes ? Epidemiological data from 20 European studies.

    Article - En anglais


    The World Health Organisation Consultation recommended new diagnostic criteria for diabetes mellitus including : lowering of the diagnostic fasting plasma glucose to 7.0 mmol/l and introduction of a new category : impaired fasting glycaemia.

    The diagnostic 2-h glucose concentrations for diabetes and for impaired glucose tolerance were unchanged.

    This study identifies fasting plasma glucose concentrations predicting a diabetic 2-h plasma glucose of 11.1 mmol/l or more, analyses the sensitivity and specificity of different screening strategies for diabetes and describes the cardiovascular risk profile in people with impaired fasting glycaemia.


    European population based studies (n=17) or large, representative samples of employees (n=3) with both fasting and 2-h post load glucose concentrations following 75-g oral glucose tolerance tests were included (18 918 men and 10 190 women).

    The Iceland study (8881 men and 9407 women) is presented separately as a 50-g glucose load was used.


    The fasting plasma glucose predicting a 2-h plasma glucose of 11.1 mmol/l or more with optimal sensitivity and specificity was a) 5.8 mmol/l in women and 6.4 mmol/l in men ; b) independent of age ; c) increased with obesity.

    Fasting plasma glucose of 7.0/7.8 mmol/l or more predicted a diabetic 2-h plasma glucose with sensitivities of 49.0/29.8% and specificities of 98.2/99.7%, respectively.



    Mots-clés Pascal : Jeûne alimentaire, Glycémie, Facteur risque, Diagnostic, Anomalie tolérance glucose, Epidémiologie, Diabète, Complication, Appareil circulatoire pathologie, Endocrinopathie, Homme, Europe

    Mots-clés Pascal anglais : Fasting, Glycemia, Risk factor, Diagnosis, Impaired glucose tolerance, Epidemiology, Diabetes mellitus, Complication, Cardiovascular disease, Endocrinopathy, Human, Europe

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0327320

    Code Inist : 002B21E01A. Création : 16/11/1999.