Is fasting glucose sufficient to define diabetes ? Epidemiological data from 20 European studies.
The World Health Organisation Consultation recommended new diagnostic criteria for diabetes mellitus including : lowering of the diagnostic fasting plasma glucose to 7.0 mmol/l and introduction of a new category : impaired fasting glycaemia.
The diagnostic 2-h glucose concentrations for diabetes and for impaired glucose tolerance were unchanged.
This study identifies fasting plasma glucose concentrations predicting a diabetic 2-h plasma glucose of 11.1 mmol/l or more, analyses the sensitivity and specificity of different screening strategies for diabetes and describes the cardiovascular risk profile in people with impaired fasting glycaemia.
European population based studies (n=17) or large, representative samples of employees (n=3) with both fasting and 2-h post load glucose concentrations following 75-g oral glucose tolerance tests were included (18 918 men and 10 190 women).
The Iceland study (8881 men and 9407 women) is presented separately as a 50-g glucose load was used.
The fasting plasma glucose predicting a 2-h plasma glucose of 11.1 mmol/l or more with optimal sensitivity and specificity was a) 5.8 mmol/l in women and 6.4 mmol/l in men ; b) independent of age ; c) increased with obesity.
Fasting plasma glucose of 7.0/7.8 mmol/l or more predicted a diabetic 2-h plasma glucose with sensitivities of 49.0/29.8% and specificities of 98.2/99.7%, respectively.
Mots-clés Pascal : Jeûne alimentaire, Glycémie, Facteur risque, Diagnostic, Anomalie tolérance glucose, Epidémiologie, Diabète, Complication, Appareil circulatoire pathologie, Endocrinopathie, Homme, Europe
Mots-clés Pascal anglais : Fasting, Glycemia, Risk factor, Diagnosis, Impaired glucose tolerance, Epidemiology, Diabetes mellitus, Complication, Cardiovascular disease, Endocrinopathy, Human, Europe
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0327320
Code Inist : 002B21E01A. Création : 16/11/1999.