Exposure of humans and domestic animals to Cylindrospermopsis raciborskii and its associated toxin cylindrospermopsin in their drinking water will normally be by ingestion.
Studies of the cyanobacterium to date have involved dosing mice by the intraperitoneal route, which excludes the possible influence on its toxicity of the alimentary tract barrier.
In the present study, outbred MF1 male mice were fasted overnight and then given a single oral dose suspended in normal saline of freeze-dried C. raciborskii culture containing 0.2% cylindrospermopsin.
The median lethal dose was in the range 4.4-6.9 mg/kg alkaloid equivalent.
Death occurred from 2 to 6 days after dosing, and pathological changes included marked fatty liver, often with periacinar coagulative necrosis, acute renal tubular necrosis, atrophy of the thymic cortex and the lymphoid follicles in the spleen, subepicardial and myocardial hemorrhages, and multiple ulcerations of the esophageal part of the gastric mucosa.
The syndrome was consistent with that already reported for cylindrospermopsin dosed parenterally.
Mots-clés Pascal : Ingestion, Eau potable, Santé et environnement, Toxicité, Voie orale, Dose létale, Analyse risque, Souris, Rodentia, Mammalia, Vertebrata, Alcaloïde, Queensland, Australie, Océanie, Intoxication, Animal laboratoire, Cyanobacteria, Bactérie, Toxine, Zone tropicale, Cylindrospermopsis raciborskii, Cylindrospermopsine
Mots-clés Pascal anglais : Ingestion, Drinking water, Health and environment, Toxicity, Oral administration, Lethal dose, Risk analysis, Mouse, Rodentia, Mammalia, Vertebrata, Alkaloid, Queensland, Australia, Oceania, Poisoning, Laboratory animal, Cyanobacteria, Bacteria, Toxin, Tropical zone
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0327284
Code Inist : 002A05B10. Création : 16/11/1999.