Stability of cylindrospermopsin, the toxin from the cyanobacterium, Cylindrospermopsis raciborskii : Effect of pH, temperature, and sunlight on decomposition.
Cylindrospermopsin is a powerful hepatotoxin produced by the cyanobacterium Cylindrospermopsis raciborskii.
It is considered a potential threat to livestock, wildlife, and humans, and is the suspected cause of an outbreak of hepatoenteritis on Palm Island, Queensland, Australia, and various stock poisoning incidents around Australia.
In this study, the stability of cylindrospermopsin was investigated using different parameters, including visible and UV light, sunlight, temperature and pH.
Cylindrospermopsin decomposes rapidly (half-life of 1.5 h) when exposed to sunlight in an algal extract solution ; however, no decomposition was recorded in pure cylindrospermopsin and Milli-Q water solutions.
Cylindrospermopsin decomposes slowly in temperatures ranging from 4 to 50°C at pH 7. After 10 weeks at 50°C, cylindrospermopsin had degraded to 57% of the original concentration.
This degradation was accompanied by an increase in another compound which is believed to be structurally related to cylindrospermopsin.
Boiling does not cause a significant degradation of cylindrospermopsin within 15 min.
Initial investigations indicate that cylindrospermopsin is degraded slowly under artificial light ranging from 42,29, and 9 muE m-1 s-1and in darkness.
Degradation of cylindrospermopsin was not affected by changes in pH.
Experiments were performed in sterile conditions.
Mots-clés Pascal : pH, Température, Lumière, Dégradation chimique, Stabilité chimique, Toxicité, Santé et environnement, Alcaloïde, Queensland, Australie, Océanie, Milieu eau douce, Facteur milieu, Cyanobacteria, Bactérie, Toxine, Cylindrospermopsis raciborskii, Cylindrospermopsine
Mots-clés Pascal anglais : pH, Temperature, Light, Chemical degradation, Chemical stability, Toxicity, Health and environment, Alkaloid, Queensland, Australia, Oceania, Freshwater environment, Environmental factor, Cyanobacteria, Bacteria, Toxin
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0327280
Code Inist : 002A05B10. Création : 16/11/1999.