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  1. Increased risk of sensory neuropathy in workers with chloracne after exposure to 2,3,7,8-polychlorinated dioxins and furans.

    Article - En anglais


    The existence of a peripheral neuropathy after exposure to polychlorinated dioxins (PCDD) is still discussed, as studies concerning dioxin effects on the peripheral nervous system are rare and contradictory.

    Material and methods

    Clinical and neurophysiological examinations (motor conduction velocity of the peroneal nerve, sensory conduction velocities of the sural and ulnar nerves) were made in 156 dioxin exposed workers (42 with, 114 without cloracne) from one pesticide producing plant.

    Because of known risk factors for peripheral neuropathy, 7 workers with and 28 without cloracne were excluded from further analysis.


    Workers with chloracne had a significantly higher exposure against PCDD as documented by back calculated lipid levels.

    They complained significantly more often of sexual impotence (28.6% compared to 5.8% of workers without chloracne, P<0.001), had significantly more frequent clinical signs of a sensory neuropathy (=abnormal sensory findings plus deep tendon reflex abnormalities) restricted to the legs (17.1% compared to 1.2%, P<0.001), had significantly more frequent >=2 neurophysiologic abnormalities (34.3% compared to 14.0%, P<0.025), and had significantly lower mean amplitudes of the motor compound muscle potential of the peroneal nerve.


    PCDD has a mild toxic effect on the peripheral nervous system manifesting as mild sensory neuropathy of the legs in a minority of the most severely exposed persons.

    Mots-clés Pascal : Exposition, Dibenzo-p-dioxine(2,3,7,8-tétrachloro), Chlore, Acné chlorique, Furane, Pesticide, Polyneuropathie périphérique sensitive, Vitesse conduction, Conduction nerveuse, Complication, Facteur risque, Médecine travail, Toxicologie, Adulte, Homme, Peau pathologie, Système nerveux pathologie, Nerf périphérique pathologie, Electrodiagnostic

    Mots-clés Pascal anglais : Exposure, Chlorine, Chlorine acne, Furan, Pesticides, Sensory polyneuropathy, Conduction velocity, Nerve conduction, Complication, Risk factor, Occupational medicine, Toxicology, Adult, Human, Skin disease, Nervous system diseases, Peripheral nerve disease, Electrodiagnosis

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0321750

    Code Inist : 002B03G. Création : 16/11/1999.