Differences in genetic susceptibility to tobacco-induced carcinogenesis appear to modulate an individual's risk of squamous-cell carcinoma of the head and neck (SCCHN).
Risk for SCCHN may be associated with the null alleles of the carcinogen-metabolizing genes glutathione-S-transferase (GST) TI and GSTMI.
In this study, we evaluated the association between GSTMI and GSTTI null genotypes and risk of SCCHN in a matched case-control study of 162 patients with SCCHN and 315 healthy controls.
Our results showed that 53.1% of cases and 42.9% of controls were null for GSTMI, whereas 32.7% of cases and 17.5% of controls were null for GSTTI (p<0.05 and p<0.001, respectively).
Furthermore, 19.8% of cases but only 7.9% of controls were null for both genes (p<0.001).
Multivariate analysis using logistic regression models, including age, sex, ethnicity, smoking status, alcohol status and GST genotypes, showed that both of these genotypes remained independent risk factors for disease [adjusted odds ratios (ORs)=1.50 and 2.27, respectively ; 95% confidence intervals (Cls)=1.01-2.23 and 1.43-3.60, respectively).
When the genotypes were divided into neither null, either null or both null, there was a dose-response relationship (adjusted OR=1.50,95% Cl=0.98-2.30) for the either-null group and (adjusted OR=3.64,95% Cl=1.94-6.84) for the both-null group (p<0.001, trend test). (...)
Mots-clés Pascal : Carcinome épidermoïde, Tête cou, Glutathione transferase, Transferases, Enzyme, Polymorphisme, Gène, Variabilité génétique, Génotype, Facteur risque, Epidémiologie, Etude cas témoin, Etats Unis, Amérique du Nord, Amérique, Homme, Tumeur maligne, ORL pathologie, Génétique
Mots-clés Pascal anglais : Squamous cell carcinoma, Head and neck, Glutathione transferase, Transferases, Enzyme, Polymorphism, Gene, Genetic variability, Genotype, Risk factor, Epidemiology, Case control study, United States, North America, America, Human, Malignant tumor, ENT disease, Genetics
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0315712
Code Inist : 002B10A01. Création : 16/11/1999.