Objective To associate Helicobacter pylori-associated antibodies with clinical disease in groups of patients with duodenal ulcer, gastric adenocarcinoma, oesophageal adenocarcinoma and normal mucosa.
Design Prospective observational sero-epidemiology study.
Identification of consecutive in-patients with duodenal ulcer, gastric adenocarcinoma, oesophageal adenocarcinoma and normal mucosa.
Analyses of sera for antibodies to whole H. pylori, Cag A and Vac A antigens using ELISA and Western blot Statistical analyses.
Setting Walsgrave Hospital, Coventry, a district general hospital that serves a population of 350 000.
Participants Consecutive in-patients with an endoscopic diagnosis of duodenal ulcer (n=31), gastric adenocarcinoma (n=31), oesophageal adenocarcinoma (n=40) and normal mucosa (n=46).
Main outcome measures A profile of antibodies was constructed for each patient group and between-group comparisons were made.
A logistic regression model determined the H. pylori-associated antibody that could best predict a patient's diagnosis.
A discriminatory power for each antibody was calculated.
Results Whole H.
Pylori, Cag A and Vac A antibodies are found more commonly in duodenal ulcer patients when compared to oesophageal adenocarcinoma (P<0.003) and normal mucosa patients (P<0.015).
Similarly, gastric adenocarcinoma patients have antibodies to whole H. pylori, Cag A and Vac A more frequently than oesophageal adenocarcinoma (P<0.002) and normal mucosa patients (P<0.006). (...)
Mots-clés Pascal : Ulcère, Duodénum, Prévalence, Helicobacter pylori, Spirillaceae, Spirillales, Bactérie, Anticorps, Association, Adénocarcinome, Estomac, Oesophage, Virulence, Muqueuse, Homme, Royaume Uni, Europe, Appareil digestif pathologie, Intestin pathologie, Bactériose, Infection, Tumeur maligne, Estomac pathologie, Immunopathologie
Mots-clés Pascal anglais : Ulcer, Duodenum, Prevalence, Helicobacter pylori, Spirillaceae, Spirillales, Bacteria, Antibody, Association, Adenocarcinoma, Stomach, Esophagus, Virulence, Mucosa, Human, United Kingdom, Europe, Digestive diseases, Intestinal disease, Bacteriosis, Infection, Malignant tumor, Gastric disease, Immunopathology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0313257
Code Inist : 002B05B02F. Création : 16/11/1999.