logo BDSP

Base documentaire


  1. Helicobacter pylori-associated antibodies in patients with duodenal ulcer, gastric and oesophageal adenocarcinoma.

    Article - En anglais

    Objective To associate Helicobacter pylori-associated antibodies with clinical disease in groups of patients with duodenal ulcer, gastric adenocarcinoma, oesophageal adenocarcinoma and normal mucosa.

    Design Prospective observational sero-epidemiology study.

    Identification of consecutive in-patients with duodenal ulcer, gastric adenocarcinoma, oesophageal adenocarcinoma and normal mucosa.

    Analyses of sera for antibodies to whole H. pylori, Cag A and Vac A antigens using ELISA and Western blot Statistical analyses.

    Setting Walsgrave Hospital, Coventry, a district general hospital that serves a population of 350 000.

    Participants Consecutive in-patients with an endoscopic diagnosis of duodenal ulcer (n=31), gastric adenocarcinoma (n=31), oesophageal adenocarcinoma (n=40) and normal mucosa (n=46).

    Main outcome measures A profile of antibodies was constructed for each patient group and between-group comparisons were made.

    A logistic regression model determined the H. pylori-associated antibody that could best predict a patient's diagnosis.

    A discriminatory power for each antibody was calculated.

    Results Whole H.

    Pylori, Cag A and Vac A antibodies are found more commonly in duodenal ulcer patients when compared to oesophageal adenocarcinoma (P<0.003) and normal mucosa patients (P<0.015).

    Similarly, gastric adenocarcinoma patients have antibodies to whole H. pylori, Cag A and Vac A more frequently than oesophageal adenocarcinoma (P<0.002) and normal mucosa patients (P<0.006). (...)

    Mots-clés Pascal : Ulcère, Duodénum, Prévalence, Helicobacter pylori, Spirillaceae, Spirillales, Bactérie, Anticorps, Association, Adénocarcinome, Estomac, Oesophage, Virulence, Muqueuse, Homme, Royaume Uni, Europe, Appareil digestif pathologie, Intestin pathologie, Bactériose, Infection, Tumeur maligne, Estomac pathologie, Immunopathologie

    Mots-clés Pascal anglais : Ulcer, Duodenum, Prevalence, Helicobacter pylori, Spirillaceae, Spirillales, Bacteria, Antibody, Association, Adenocarcinoma, Stomach, Esophagus, Virulence, Mucosa, Human, United Kingdom, Europe, Digestive diseases, Intestinal disease, Bacteriosis, Infection, Malignant tumor, Gastric disease, Immunopathology

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0313257

    Code Inist : 002B05B02F. Création : 16/11/1999.