Distal renal tubular acidosis is a common health problem in northeastern Thailand, with the population background of the low potassium intake, low urine citrate, and decreased red blood cell Na-K adenosine triphosphatase (ATPase) activity and the environment of the high soil vanadium.
The disease is usually seen in the people with low socioeconomic status in summer.
The patients have decreased gastric acidity and low urine potasslum.
There are varying degrees of renal function from normal to Impairment Gastric hypoacidity Is an important clue.
Defects in H-K ATPase and anion exchange (AE2) mechanism are considered.
The urine vanadium is higher In the patients than that of normal rural northeastern villagers.
Inhibition of H-K ATPase by vanadium seems possible and requires more supporting evidence.
AE1 gene mutation Is noted in few patients.
The cause of dRTA Is not apparent.
The AE2 gene and H-K ATPase gene remain to be studied.
Both environmental and genetic factors could contribute to the pethogenesis of the disease.
Mots-clés Pascal : Acidose, Tubulopathie, Héréditaire, Adenosinetriphosphatase, Hydrolases, Enzyme, Activité enzymatique, Thaïlande, Asie, Physiopathologie, Déterminisme génétique, Epidémiologie, Homme, Mongoloïde, Appareil urinaire pathologie, Rein pathologie, Maladie héréditaire
Mots-clés Pascal anglais : Acidosis, Tubulopathy, Hereditary, Adenosinetriphosphatase, Hydrolases, Enzyme, Enzymatic activity, Thailand, Asia, Pathophysiology, Genetic determinism, Epidemiology, Human, Mongoloid, Urinary system disease, Kidney disease, Genetic disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0312721
Code Inist : 002B14A03. Création : 16/11/1999.