It is difficult to evaluate the extent of stress in cases of suspected child abuse/neglect in a medico-legal autopsy.
We have previously reported that stress due to abuse/neglect was found to have led to thymic involution.
To elucidate the influence upon thymocytes differentiation, we compared the proportion of the thymocyte subpopulation in the thymus of a neglected child with one in an age-matched control obtained from cardiac surgery.
We found that the relative number of CD4+CD8+double positive (DP) thymocytes decreased in the neglected child.
It was presumed that the selective decrease in the number of the immature DP thymocytes with CD3-to low bcl-2low caused the thymic involution in the neglected child.
It was suggested that an alteration in the proportion of thymocytes subpopulation might be used as an index of stress in cases of child abuse/neglect.
Mots-clés Pascal : Enfant maltraité, Stress, Thymus, Involution, Thymocyte, Cytométrie flux, Histologie, Médecine légale, Diagnostic, Autopsie, Enfant, Homme, Victimologie
Mots-clés Pascal anglais : Child abuse, Stress, Thymus gland, Involution, Thymocyte, Flow cytometry, Histology, Legal medicine, Diagnosis, Autopsy, Child, Human, Victimology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0311434
Code Inist : 002B30A10. Création : 16/11/1999.