Objective To assess whether inflammatory bowel disease (IBD) is more prevalent in young Asians than Europeans living in Great Britain.
Design Longitudinal birth cohort study of all those born 5-11 April 1970 in Great Britain - the 1970 British Cohort Study (BCS70).
Methods The relationship of a diagnosis of ulcerative colitis or Crohn's disease by age 26 years with ethnic origin was investigated among 8432 cohort members with complete data using multiple logistic regression.
We adjusted for potential confounding factors, household crowding and sex, as well as for a family history of IBD.
Results Young Asians born in Britain were significantly more likely than indigenous Europeans to have a diagnosis of IBD by age 26 years, with relative odds of 6.10 (95% CI 2.14-17.33).
This group of cohort members had ethnic origins in India, Pakistan or Bangladesh (although none of those from Bangladesh had IBD).
This relationship remained statistically significant after adjustment for the potential confounding factors and family history of IBD.
Conclusion Young Asians who were born in Britain are at a significantly higher risk of developing IBD than the indigenous European population.
This may reflect a greater genetic predisposition to IBD that is uncovered by exposure to environmental factors.
Mots-clés Pascal : Entérite Crohn, Rectocolite ulcérohémorragique, Etude cohorte, Ethnie, Asiatique, Facteur risque, Etude familiale, Prévalence, Diagnostic, Royaume Uni, Europe, Adolescent, Homme, Appareil digestif pathologie, Intestin pathologie, Maladie inflammatoire, Race
Mots-clés Pascal anglais : Crohn disease, Ulcerative colitis, Cohort study, Ethnic group, Asiatic, Risk factor, Family study, Prevalence, Diagnosis, United Kingdom, Europe, Adolescent, Human, Digestive diseases, Intestinal disease, Inflammatory disease, Race
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0311344
Code Inist : 002B13B03. Création : 16/11/1999.